Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation
IntroductionPreterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones a...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1090499/full |
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| author | David Ramiro-Cortijo David Ramiro-Cortijo David Ramiro-Cortijo Pratibha Singh Gloria Herranz Carrillo Andrea Gila-Díaz María A. Martín-Cabrejas Camilia R. Martin Camilia R. Martin Silvia M. Arribas Silvia M. Arribas |
| author_facet | David Ramiro-Cortijo David Ramiro-Cortijo David Ramiro-Cortijo Pratibha Singh Gloria Herranz Carrillo Andrea Gila-Díaz María A. Martín-Cabrejas Camilia R. Martin Camilia R. Martin Silvia M. Arribas Silvia M. Arribas |
| author_sort | David Ramiro-Cortijo |
| collection | DOAJ |
| description | IntroductionPreterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones are present in BM, it is possible that their levels may equilibrate deficiencies improving infant growth. We aimed to assess 1) the BM levels of ghrelin, resistin, leptin, insulin, peptide YY, and the gastrointestinal peptide in women with preterm and term labor; 2) the relationship between BM hormones and neonatal growth; and 3) the influence of maternal body composition and diet on these BM hormones.MethodsBM from 48 women (30 term and 18 preterm labor) was collected at days 7, 14, and 28 of lactation. Maternal body composition was evaluated by bioimpedance, and neonate anthropometric parameters were collected from medical records. The maternal dietary pattern was assessed by a 72-h dietary recall at days 7 and 28 of lactation. BM hormones were analyzed by the U-Plex Ultra-sensitive method. Data were analyzed using linear regression models. BM from women with preterm labor had lower ghrelin levels, with the other hormones being significantly higher compared to women with term delivery.ResultsIn premature infants, growth was positively associated with BM ghrelin, while, in term infants, it was positively associated with insulin and negatively with peptide YY. In the first week of lactation, women with preterm labor had higher body fat compared to women with term labor. In this group, ghrelin levels were positively associated with maternal body fat and with fiber and protein intake. In women with term labor, no associations between anthropometric parameters and BM hormones were found, and fiber intake was negatively associated with peptide YY.DiscussionPreterm labor is a factor influencing the levels of BM adipokines and gut hormones, with BM ghrelin being a relevant hormone for premature infant growth. Since ghrelin is lower in BM from women with preterm labor and the levels are associated with maternal fat storage and some dietary components, our data support the importance to monitor diet and body composition in women who gave birth prematurely to improve the BM hormonal status. |
| first_indexed | 2024-04-10T06:15:58Z |
| format | Article |
| id | doaj.art-40f6d84dff8b46f9bbb1106f7a4df15f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T06:15:58Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-40f6d84dff8b46f9bbb1106f7a4df15f2023-03-02T07:07:57ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-03-011410.3389/fendo.2023.10904991090499Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactationDavid Ramiro-Cortijo0David Ramiro-Cortijo1David Ramiro-Cortijo2Pratibha Singh3Gloria Herranz Carrillo4Andrea Gila-Díaz5María A. Martín-Cabrejas6Camilia R. Martin7Camilia R. Martin8Silvia M. Arribas9Silvia M. Arribas10Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, SpainDivision of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesInstituto Universitario de Estudios de la Mujer (IUEM), Universidad Autónoma de Madrid, Madrid, SpainDivision of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDivision of Neonatology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, SpainDepartment of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, SpainDepartment of Agricultural Chemistry and Food Science, Institute of Food Science Research (CIAL), Universidad Autónoma de Madrid, Consejo Superior de Investigación Científica (CSIC), Madrid, SpainDepartment of Neonatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDivision of Translational Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United StatesDepartment of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, SpainInstituto Universitario de Estudios de la Mujer (IUEM), Universidad Autónoma de Madrid, Madrid, SpainIntroductionPreterm birth is associated with altered growth patterns and an increased risk of cardiometabolic diseases, with breast milk (BM) being a counteracting factor. Preterm infants also show alterations in adipokines and gut hormones influencing appetite and metabolism. Since these hormones are present in BM, it is possible that their levels may equilibrate deficiencies improving infant growth. We aimed to assess 1) the BM levels of ghrelin, resistin, leptin, insulin, peptide YY, and the gastrointestinal peptide in women with preterm and term labor; 2) the relationship between BM hormones and neonatal growth; and 3) the influence of maternal body composition and diet on these BM hormones.MethodsBM from 48 women (30 term and 18 preterm labor) was collected at days 7, 14, and 28 of lactation. Maternal body composition was evaluated by bioimpedance, and neonate anthropometric parameters were collected from medical records. The maternal dietary pattern was assessed by a 72-h dietary recall at days 7 and 28 of lactation. BM hormones were analyzed by the U-Plex Ultra-sensitive method. Data were analyzed using linear regression models. BM from women with preterm labor had lower ghrelin levels, with the other hormones being significantly higher compared to women with term delivery.ResultsIn premature infants, growth was positively associated with BM ghrelin, while, in term infants, it was positively associated with insulin and negatively with peptide YY. In the first week of lactation, women with preterm labor had higher body fat compared to women with term labor. In this group, ghrelin levels were positively associated with maternal body fat and with fiber and protein intake. In women with term labor, no associations between anthropometric parameters and BM hormones were found, and fiber intake was negatively associated with peptide YY.DiscussionPreterm labor is a factor influencing the levels of BM adipokines and gut hormones, with BM ghrelin being a relevant hormone for premature infant growth. Since ghrelin is lower in BM from women with preterm labor and the levels are associated with maternal fat storage and some dietary components, our data support the importance to monitor diet and body composition in women who gave birth prematurely to improve the BM hormonal status.https://www.frontiersin.org/articles/10.3389/fendo.2023.1090499/fullhormonesbreast milkprematuritygrowthbody compositiondiet pattern |
| spellingShingle | David Ramiro-Cortijo David Ramiro-Cortijo David Ramiro-Cortijo Pratibha Singh Gloria Herranz Carrillo Andrea Gila-Díaz María A. Martín-Cabrejas Camilia R. Martin Camilia R. Martin Silvia M. Arribas Silvia M. Arribas Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation Frontiers in Endocrinology hormones breast milk prematurity growth body composition diet pattern |
| title | Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_full | Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_fullStr | Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_full_unstemmed | Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_short | Association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| title_sort | association of maternal body composition and diet on breast milk hormones and neonatal growth during the first month of lactation |
| topic | hormones breast milk prematurity growth body composition diet pattern |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1090499/full |
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