The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis
Abstract Background Numerous case-control studies have reported associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer; however, the results were inconsistent. The aim of this meta-analysis was to further clarify the effects of IL-17 polymorphisms on colorectal cancer suscep...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02586-2 |
| _version_ | 1828378957850869760 |
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| author | Gaoming Li Jingfu Ma Ning Zhang Xiaogang Li Fangfang Li Yuxing Jiang |
| author_facet | Gaoming Li Jingfu Ma Ning Zhang Xiaogang Li Fangfang Li Yuxing Jiang |
| author_sort | Gaoming Li |
| collection | DOAJ |
| description | Abstract Background Numerous case-control studies have reported associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer; however, the results were inconsistent. The aim of this meta-analysis was to further clarify the effects of IL-17 polymorphisms on colorectal cancer susceptibility. Materials and method Relevant studies were extracted from the electronic databases PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CMB) up to April 2021. The odds ratio and 95% confidence interval were used to estimate the strength of the associations. Results Ten articles including 2599 cases and 2845 controls were enrolled in our research after strict literature screening. Highly significant associations between the IL-17A rs2275913 polymorphism and increased colorectal cancer susceptibility were observed in all five gene models (allelic, dominant, recessive, homozygous, and heterozygous models), and subgroup analysis based on ethnicity revealed that these associations existed not only in the Asian population but also in the Caucasian population. However, the results showed no significantly elevated colorectal cancer risk correlated with the IL-17F rs763780 polymorphism, and a slightly lower colorectal cancer susceptibility for the Caucasian population was discovered in the recessive and homozygous models of this mutation. Conclusion The IL-17A rs2275913 polymorphism may be an independent risk factor contributing to colorectal cancer susceptibility, while the IL-17F rs763780 polymorphism may decrease susceptibility to colorectal cancer. Future studies with large-scale samples are warranted to identify these associations. |
| first_indexed | 2024-12-10T03:31:05Z |
| format | Article |
| id | doaj.art-40f8085ad45744928a0d65da24201ddc |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-10T03:31:05Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-40f8085ad45744928a0d65da24201ddc2022-12-22T02:03:48ZengBMCWorld Journal of Surgical Oncology1477-78192022-04-0120111310.1186/s12957-022-02586-2The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysisGaoming Li0Jingfu Ma1Ning Zhang2Xiaogang Li3Fangfang Li4Yuxing Jiang5Center for Disease Control and Prevention of Central Theater CommandDepartment of Intensive Care Unit, The 305 Hospital of PLADepartment of Intensive Care Unit, The 305 Hospital of PLADepartment of Intensive Care Unit, The 305 Hospital of PLADepartment of Intensive Care Unit, The 305 Hospital of PLADepartment of Intensive Care Unit, The 305 Hospital of PLAAbstract Background Numerous case-control studies have reported associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer; however, the results were inconsistent. The aim of this meta-analysis was to further clarify the effects of IL-17 polymorphisms on colorectal cancer susceptibility. Materials and method Relevant studies were extracted from the electronic databases PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CMB) up to April 2021. The odds ratio and 95% confidence interval were used to estimate the strength of the associations. Results Ten articles including 2599 cases and 2845 controls were enrolled in our research after strict literature screening. Highly significant associations between the IL-17A rs2275913 polymorphism and increased colorectal cancer susceptibility were observed in all five gene models (allelic, dominant, recessive, homozygous, and heterozygous models), and subgroup analysis based on ethnicity revealed that these associations existed not only in the Asian population but also in the Caucasian population. However, the results showed no significantly elevated colorectal cancer risk correlated with the IL-17F rs763780 polymorphism, and a slightly lower colorectal cancer susceptibility for the Caucasian population was discovered in the recessive and homozygous models of this mutation. Conclusion The IL-17A rs2275913 polymorphism may be an independent risk factor contributing to colorectal cancer susceptibility, while the IL-17F rs763780 polymorphism may decrease susceptibility to colorectal cancer. Future studies with large-scale samples are warranted to identify these associations.https://doi.org/10.1186/s12957-022-02586-2Colorectal cancerIL-17PolymorphismSusceptibilityMeta-analysis |
| spellingShingle | Gaoming Li Jingfu Ma Ning Zhang Xiaogang Li Fangfang Li Yuxing Jiang The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis World Journal of Surgical Oncology Colorectal cancer IL-17 Polymorphism Susceptibility Meta-analysis |
| title | The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis |
| title_full | The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis |
| title_fullStr | The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis |
| title_full_unstemmed | The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis |
| title_short | The associations between interleukin-17 single-nucleotide polymorphism and colorectal cancer susceptibility: a systematic review and meta-analysis |
| title_sort | associations between interleukin 17 single nucleotide polymorphism and colorectal cancer susceptibility a systematic review and meta analysis |
| topic | Colorectal cancer IL-17 Polymorphism Susceptibility Meta-analysis |
| url | https://doi.org/10.1186/s12957-022-02586-2 |
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