Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern, representing a substantial burden within the spectrum of chronic liver diseases. Despite its escalating prevalence, a definitive therapeutic strategy or efficacious pharmacological intervention for NAFLD has y...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024031062 |
| _version_ | 1827316382908284928 |
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| author | Xuehua Yan Hongbing Liu Meng Huang Yujie Zhang Binfang Zeng |
| author_facet | Xuehua Yan Hongbing Liu Meng Huang Yujie Zhang Binfang Zeng |
| author_sort | Xuehua Yan |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern, representing a substantial burden within the spectrum of chronic liver diseases. Despite its escalating prevalence, a definitive therapeutic strategy or efficacious pharmacological intervention for NAFLD has yet to receive official approval to date. While Fu Fang Qiyin granules have exhibited efficacy in addressing NAFLD, the intricacies of their underlying mechanism of action remain inadequately elucidated. In this study, we substantiated the ameliorative impact of Qiyin on highfat diet (HFD)induced NAFLD in rat models. The results of metabonomics showed that 108 potential biomarkers in serum and urine related to amino acid metabolism, energy metabolism, and pyrimidine metabolism, have returned to normal levels compared to the model group. Hepatic transcriptomics further indicated that Qiyin potentially confers protective effects against NAFLD by mediating liver inflammation and fibrosis through lumican (LUM) and decorin (DCN). In summation, our investigation provides compelling evidence affirming the therapeutic promise of Qiyin for NAFLD. It elucidates the underlying mechanistic pathways, furnishing a compelling rationale for its prospective clinical application. |
| first_indexed | 2024-03-07T19:09:10Z |
| format | Article |
| id | doaj.art-40f959f128204a94ac78024bf2f0e9c8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:14:49Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-40f959f128204a94ac78024bf2f0e9c82024-03-17T07:57:15ZengElsevierHeliyon2405-84402024-03-01105e27075Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver diseaseXuehua Yan0Hongbing Liu1Meng Huang2Yujie Zhang3Binfang Zeng4School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China; College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, 830017, People's Republic of China; Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi, Xinjiang, 830017, People's Republic of ChinaCollege of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, 830017, People's Republic of China; Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi, Xinjiang, 830017, People's Republic of ChinaCollege of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, 830017, People's Republic of China; Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi, Xinjiang, 830017, People's Republic of ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China; Corresponding author. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, 830017, People's Republic of China; Xinjiang Key Laboratory of Famous Prescription and Science of Formulas, Urumqi, Xinjiang, 830017, People's Republic of China; Corresponding author. College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, 830017, People's Republic of China.Nonalcoholic fatty liver disease (NAFLD) has emerged as a prominent global health concern, representing a substantial burden within the spectrum of chronic liver diseases. Despite its escalating prevalence, a definitive therapeutic strategy or efficacious pharmacological intervention for NAFLD has yet to receive official approval to date. While Fu Fang Qiyin granules have exhibited efficacy in addressing NAFLD, the intricacies of their underlying mechanism of action remain inadequately elucidated. In this study, we substantiated the ameliorative impact of Qiyin on highfat diet (HFD)induced NAFLD in rat models. The results of metabonomics showed that 108 potential biomarkers in serum and urine related to amino acid metabolism, energy metabolism, and pyrimidine metabolism, have returned to normal levels compared to the model group. Hepatic transcriptomics further indicated that Qiyin potentially confers protective effects against NAFLD by mediating liver inflammation and fibrosis through lumican (LUM) and decorin (DCN). In summation, our investigation provides compelling evidence affirming the therapeutic promise of Qiyin for NAFLD. It elucidates the underlying mechanistic pathways, furnishing a compelling rationale for its prospective clinical application.http://www.sciencedirect.com/science/article/pii/S2405844024031062Nonalcoholic fatty liver diseaseQiyin granulesMetabonomicsProteomicGraph abstract |
| spellingShingle | Xuehua Yan Hongbing Liu Meng Huang Yujie Zhang Binfang Zeng Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease Heliyon Nonalcoholic fatty liver disease Qiyin granules Metabonomics Proteomic Graph abstract |
| title | Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease |
| title_full | Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease |
| title_fullStr | Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease |
| title_full_unstemmed | Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease |
| title_short | Integrative proteomics and metabolomics explore the effect and mechanism of Qiyin granules on improving nonalcoholic fatty liver disease |
| title_sort | integrative proteomics and metabolomics explore the effect and mechanism of qiyin granules on improving nonalcoholic fatty liver disease |
| topic | Nonalcoholic fatty liver disease Qiyin granules Metabonomics Proteomic Graph abstract |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024031062 |
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