Preparation of Modified RNA Sequences for Biological Research
Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ribonucleoside phosphoramidites, their templa...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2005-11-01
|
| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4075 |
| _version_ | 1811320311109386240 |
|---|---|
| author | Stefan Pitsch Philipp Wenter Alfred Stutz Luc Reymond Sébastien Porcher Andreas Peer Evelyne Muller Muthulaniappan Meyyappan Frédéric Meylan Cyrille Denarie Damian Ackermann Xiaolin Wu |
| author_facet | Stefan Pitsch Philipp Wenter Alfred Stutz Luc Reymond Sébastien Porcher Andreas Peer Evelyne Muller Muthulaniappan Meyyappan Frédéric Meylan Cyrille Denarie Damian Ackermann Xiaolin Wu |
| author_sort | Stefan Pitsch |
| collection | DOAJ |
| description |
Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ribonucleoside phosphoramidites,
their template-directed enzymatic ligation, and some examples of modified nucleotides, designed to promote structural and biological studies.
|
| first_indexed | 2024-04-13T12:57:34Z |
| format | Article |
| id | doaj.art-40fa4024082f40dcaf6a93389e43a849 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T12:57:34Z |
| publishDate | 2005-11-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-40fa4024082f40dcaf6a93389e43a8492022-12-22T02:46:01ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242005-11-01591110.2533/000942905777675633Preparation of Modified RNA Sequences for Biological ResearchStefan PitschPhilipp WenterAlfred StutzLuc ReymondSébastien PorcherAndreas PeerEvelyne MullerMuthulaniappan MeyyappanFrédéric MeylanCyrille DenarieDamian AckermannXiaolin Wu Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ribonucleoside phosphoramidites, their template-directed enzymatic ligation, and some examples of modified nucleotides, designed to promote structural and biological studies. https://chimia.ch/chimia/article/view/4075LigationNucleic acidsOrganic synthesisPhosphoramiditesRna |
| spellingShingle | Stefan Pitsch Philipp Wenter Alfred Stutz Luc Reymond Sébastien Porcher Andreas Peer Evelyne Muller Muthulaniappan Meyyappan Frédéric Meylan Cyrille Denarie Damian Ackermann Xiaolin Wu Preparation of Modified RNA Sequences for Biological Research CHIMIA Ligation Nucleic acids Organic synthesis Phosphoramidites Rna |
| title | Preparation of Modified RNA Sequences for Biological Research |
| title_full | Preparation of Modified RNA Sequences for Biological Research |
| title_fullStr | Preparation of Modified RNA Sequences for Biological Research |
| title_full_unstemmed | Preparation of Modified RNA Sequences for Biological Research |
| title_short | Preparation of Modified RNA Sequences for Biological Research |
| title_sort | preparation of modified rna sequences for biological research |
| topic | Ligation Nucleic acids Organic synthesis Phosphoramidites Rna |
| url | https://chimia.ch/chimia/article/view/4075 |
| work_keys_str_mv | AT stefanpitsch preparationofmodifiedrnasequencesforbiologicalresearch AT philippwenter preparationofmodifiedrnasequencesforbiologicalresearch AT alfredstutz preparationofmodifiedrnasequencesforbiologicalresearch AT lucreymond preparationofmodifiedrnasequencesforbiologicalresearch AT sebastienporcher preparationofmodifiedrnasequencesforbiologicalresearch AT andreaspeer preparationofmodifiedrnasequencesforbiologicalresearch AT evelynemuller preparationofmodifiedrnasequencesforbiologicalresearch AT muthulaniappanmeyyappan preparationofmodifiedrnasequencesforbiologicalresearch AT fredericmeylan preparationofmodifiedrnasequencesforbiologicalresearch AT cyrilledenarie preparationofmodifiedrnasequencesforbiologicalresearch AT damianackermann preparationofmodifiedrnasequencesforbiologicalresearch AT xiaolinwu preparationofmodifiedrnasequencesforbiologicalresearch |