| Summary: | Twelve new lanostane triterpenoids (<b>1</b>–<b>5</b>, <b>7</b>–<b>13</b>) were isolated from the fruiting bodies of the fungus <i>Ganoderma australe</i>. The structures of the new compounds were elucidated by extensive 1D and 2D NMR, and HRESIMS spectroscopic analysis. All the triterpenes are featured by 20(22)<i>E</i> configurations which are uncommon in the <i>Ganoderma</i> triterpene family. The absolute configuration of the C-25 of compounds <b>1</b>, <b>2</b>, and <b>6</b> were determined by the phenylglycine methyl ester (PGME) method. A postulated biosynthetic pathway for compound <b>1</b> was discussed. This study opens new insights into the secondary metabolites of the chemically underinvestigated fungus <i>G. australe</i>.
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