Study of Kinetics of degradation of cefuroxime axetil in acetone solution

In order to study the stability of cefuroxime axetil acetone solution, by using high-performance liquid chromatography, the single factor test was conducted to study the variation ofcefuroxime axetilcontent in the solution with time under different conditions such as the initial solution pH, tempera...

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Main Authors: Zhefan ZHANG, Baoshu LIU, Kang HAN, Junli ZHANG, Hua SUN
Format: Article
Language:zho
Published: Hebei University of Science and Technology 2020-08-01
Series:Journal of Hebei University of Science and Technology
Subjects:
Online Access:http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b202004007&flag=1&journal_
_version_ 1818879960780111872
author Zhefan ZHANG
Baoshu LIU
Kang HAN
Junli ZHANG
Hua SUN
author_facet Zhefan ZHANG
Baoshu LIU
Kang HAN
Junli ZHANG
Hua SUN
author_sort Zhefan ZHANG
collection DOAJ
description In order to study the stability of cefuroxime axetil acetone solution, by using high-performance liquid chromatography, the single factor test was conducted to study the variation ofcefuroxime axetilcontent in the solution with time under different conditions such as the initial solution pH, temperature and oxidant species. The chemical reaction kinetics method was used to establish the degradation reaction kinetics models of cefuroxime axetil under different conditions. The model parameters were obtained by regression, and the half-life(t1/2) was predicted. The degradation mechanism of cefuroxime axetil was analyzed from the molecular scale by Materials Studio simulation software. The results show that the degradation of cefuroxime axetil acetone solution under the above conditions is in line with the first-order reaction kinetics. When pH is lower than 9.54, cefuroxime axetil acetone solution is basically stable. When pH is higher than 9.54, the chemical stability of cefuroxime axetil acetone solution becomes worse, the degradation rate increases rapidly, and the color of the solution becomes darker with the increase of pH value. The chemical stability of cefuroxime axetil acetone solution decreases with the increase of temperature. The research result provides data support for production process, crystallization process design, storage and application.
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spelling doaj.art-40fc51dbf2c6482ca6ab4d16aed466132022-12-21T20:17:11ZzhoHebei University of Science and TechnologyJournal of Hebei University of Science and Technology1008-15422020-08-0141434134810.7535/hbkd.2020yx04007b202004007Study of Kinetics of degradation of cefuroxime axetil in acetone solutionZhefan ZHANG0Baoshu LIU1Kang HAN2Junli ZHANG3Hua SUN4School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, ChinaSchool of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, ChinaSchool of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, ChinaNorth China Pharmaceutical Company Limited, Shijiazhuang, Hebei 052165, ChinaSchool of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, ChinaIn order to study the stability of cefuroxime axetil acetone solution, by using high-performance liquid chromatography, the single factor test was conducted to study the variation ofcefuroxime axetilcontent in the solution with time under different conditions such as the initial solution pH, temperature and oxidant species. The chemical reaction kinetics method was used to establish the degradation reaction kinetics models of cefuroxime axetil under different conditions. The model parameters were obtained by regression, and the half-life(t1/2) was predicted. The degradation mechanism of cefuroxime axetil was analyzed from the molecular scale by Materials Studio simulation software. The results show that the degradation of cefuroxime axetil acetone solution under the above conditions is in line with the first-order reaction kinetics. When pH is lower than 9.54, cefuroxime axetil acetone solution is basically stable. When pH is higher than 9.54, the chemical stability of cefuroxime axetil acetone solution becomes worse, the degradation rate increases rapidly, and the color of the solution becomes darker with the increase of pH value. The chemical stability of cefuroxime axetil acetone solution decreases with the increase of temperature. The research result provides data support for production process, crystallization process design, storage and application.http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b202004007&flag=1&journal_chemical kinetics; hplc; cefuroxime axetil; stability; degradation
spellingShingle Zhefan ZHANG
Baoshu LIU
Kang HAN
Junli ZHANG
Hua SUN
Study of Kinetics of degradation of cefuroxime axetil in acetone solution
Journal of Hebei University of Science and Technology
chemical kinetics; hplc; cefuroxime axetil; stability; degradation
title Study of Kinetics of degradation of cefuroxime axetil in acetone solution
title_full Study of Kinetics of degradation of cefuroxime axetil in acetone solution
title_fullStr Study of Kinetics of degradation of cefuroxime axetil in acetone solution
title_full_unstemmed Study of Kinetics of degradation of cefuroxime axetil in acetone solution
title_short Study of Kinetics of degradation of cefuroxime axetil in acetone solution
title_sort study of kinetics of degradation of cefuroxime axetil in acetone solution
topic chemical kinetics; hplc; cefuroxime axetil; stability; degradation
url http://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b202004007&flag=1&journal_
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AT baoshuliu studyofkineticsofdegradationofcefuroximeaxetilinacetonesolution
AT kanghan studyofkineticsofdegradationofcefuroximeaxetilinacetonesolution
AT junlizhang studyofkineticsofdegradationofcefuroximeaxetilinacetonesolution
AT huasun studyofkineticsofdegradationofcefuroximeaxetilinacetonesolution