PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process

PLGA Microspheres of hGH of Preserved Native State Prepared Using a Self-Regulated Process

The challenges of formulating recombinant human growth hormone (rhGH) into sustained-release polymeric microspheres include two mutual causal factors, protein denaturing by the formulation process and severe initial burst release related with relative high dose. The stabilizers to protect the protei...

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Bibliographic Details
Main Authors: Jebun Nessa Diana, Ying Tao, Qiran Du, Meng Wang, Chinta Uday Kumar, Fei Wu, Tuo Jin
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
recombinant human growth hormone (rhGH)
sustained release microspheres
protein aggregation
stability
Online Access:https://www.mdpi.com/1999-4923/12/7/683

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