Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat
In 2003, the United States saw an epidemic of monkeypox that was later traced back to rodents of West Africa infected with the monkeypox virus (MPXV). Disease in the United States seemed less severe than the smallpox-like disease in the Democratic Republic of the Congo (DRC). In this study, research...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/937 |
| _version_ | 1797603196245377024 |
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| author | Parveen Kumar Benu Chaudhary Nishant Yadav Sushma Devi Ashutosh Pareek Sujatha Alla Fnu Kajal Behdin Nowrouzi-Kia Vijay Kumar Chattu Madan Mohan Gupta |
| author_facet | Parveen Kumar Benu Chaudhary Nishant Yadav Sushma Devi Ashutosh Pareek Sujatha Alla Fnu Kajal Behdin Nowrouzi-Kia Vijay Kumar Chattu Madan Mohan Gupta |
| author_sort | Parveen Kumar |
| collection | DOAJ |
| description | In 2003, the United States saw an epidemic of monkeypox that was later traced back to rodents of West Africa infected with the monkeypox virus (MPXV). Disease in the United States seemed less severe than the smallpox-like disease in the Democratic Republic of the Congo (DRC). In this study, researchers analyzed data from Central Africa: two distinct MPXV clades were confirmed by sequencing the genomes of MPXV isolates from Western Africa, the United States, and Central Africa. By comparing open reading frames across MPXV clades, scientists can infer which virus proteins might account for the observed variation in pathogenicity in humans. Monkeypox can be prevented and controlled with a better understanding of MPXV’s molecular etiology and epidemiological and clinical features. In light of the current outbreaks worldwide, we provide updated information on monkeypox for medical professionals in this review. |
| first_indexed | 2024-03-11T04:26:00Z |
| format | Article |
| id | doaj.art-40fd7a7ddc434ab0be94c82aedb1643d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:00Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-40fd7a7ddc434ab0be94c82aedb1643d2023-11-17T21:45:53ZengMDPI AGViruses1999-49152023-04-0115493710.3390/v15040937Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health ThreatParveen Kumar0Benu Chaudhary1Nishant Yadav2Sushma Devi3Ashutosh Pareek4Sujatha Alla5Fnu Kajal6Behdin Nowrouzi-Kia7Vijay Kumar Chattu8Madan Mohan Gupta9Shri Ram College of Pharmacy, Karnal 132116, Haryana, IndiaGuru Gobind Singh College of Pharmacy, Yamunanagar 135001, Haryana, IndiaB.S. Anangpuria Institute of Pharmacy, Faridabad 121004, Haryana, IndiaChitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali 304022, Rajasthan, IndiaDepartment of Engineering Management & Systems Engineering, Frank Batten College of Engineering, Old Dominion University, Norfolk, VA 23529, USADepartment of Health Promotion Sciences, University of Arizona, Tucson, AZ 85719, USADepartment of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaDepartment of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 1V7, CanadaSchool of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine 3303, Trinidad and TobagoIn 2003, the United States saw an epidemic of monkeypox that was later traced back to rodents of West Africa infected with the monkeypox virus (MPXV). Disease in the United States seemed less severe than the smallpox-like disease in the Democratic Republic of the Congo (DRC). In this study, researchers analyzed data from Central Africa: two distinct MPXV clades were confirmed by sequencing the genomes of MPXV isolates from Western Africa, the United States, and Central Africa. By comparing open reading frames across MPXV clades, scientists can infer which virus proteins might account for the observed variation in pathogenicity in humans. Monkeypox can be prevented and controlled with a better understanding of MPXV’s molecular etiology and epidemiological and clinical features. In light of the current outbreaks worldwide, we provide updated information on monkeypox for medical professionals in this review.https://www.mdpi.com/1999-4915/15/4/937monkeypox viruspoxviridaeDNAepidemicAfricaimmunization |
| spellingShingle | Parveen Kumar Benu Chaudhary Nishant Yadav Sushma Devi Ashutosh Pareek Sujatha Alla Fnu Kajal Behdin Nowrouzi-Kia Vijay Kumar Chattu Madan Mohan Gupta Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat Viruses monkeypox virus poxviridae DNA epidemic Africa immunization |
| title | Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat |
| title_full | Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat |
| title_fullStr | Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat |
| title_full_unstemmed | Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat |
| title_short | Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health Threat |
| title_sort | recent advances in research and management of human monkeypox virus an emerging global health threat |
| topic | monkeypox virus poxviridae DNA epidemic Africa immunization |
| url | https://www.mdpi.com/1999-4915/15/4/937 |
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