No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19
Adrien Chan Sui Ko,1,* Alexandre Candellier,2,* Marie Mercier,3 Cedric Joseph,1 Hortense Carette,3 Damien Basille,3 Sylvie Lion-Daolio,4 Stephanie Devaux,3 Jean-Luc Schmit,1 Jean-Philippe Lanoix,1 Claire Andrejak3 1Department of Infectious Diseases, Centre Hospitalier Universitaire A...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/no-impact-of-corticosteroid-use-during-the-acute-phase-on-persistent-s-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1811283732415381504 |
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| author | Chan Sui Ko A Candellier A Mercier M Joseph C Carette H Basille D Lion-Daolio S Devaux S Schmit JL Lanoix JP Andrejak C |
| author_facet | Chan Sui Ko A Candellier A Mercier M Joseph C Carette H Basille D Lion-Daolio S Devaux S Schmit JL Lanoix JP Andrejak C |
| author_sort | Chan Sui Ko A |
| collection | DOAJ |
| description | Adrien Chan Sui Ko,1,* Alexandre Candellier,2,* Marie Mercier,3 Cedric Joseph,1 Hortense Carette,3 Damien Basille,3 Sylvie Lion-Daolio,4 Stephanie Devaux,3 Jean-Luc Schmit,1 Jean-Philippe Lanoix,1 Claire Andrejak3 1Department of Infectious Diseases, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 2Department of Nephrology, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 3Department of Pneumology, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 4Department of Orthopedy, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France*These authors contributed equally to this workCorrespondence: Adrien Chan Sui Ko, Department of Infectious Diseases, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France, Email chansuiko.adrien@chu-amiens.frAbstract: Persistent COVID-19 symptoms may be related to residual inflammation, but no preventive treatment has been evaluated. This study aimed to analyze, in a prospective cohort, whether corticosteroid use in the acute phase of COVID-19 in hospitalized patients may reduce the risk of persistent COVID-19 symptoms. A total of 306 discharged patients, including 112 (36.6%) from the ICU, completed a structured face-to-face assessment 4 months after admission. Of these, 193 patients (63.1%) had at least one persistent symptom, mostly dyspnea (38.9%) and asthenia (37.6%). One-hundred and four patients have received corticosteroids. In multivariable adjusted regression analysis, corticosteroid use was not associated with the presence of at least one symptom (OR=1.00, 95% CI: 0.58– 1.71, p=0.99) or with the number of persistent symptoms (p=0.74). Corticosteroid use remained ineffective when analyzing the ICU subpopulation separately. Our study suggests that corticosteroid use had no impact on persistent symptoms after COVID-19 in discharged patients.Keywords: COVID-19, persistent symptoms, corticosteroid use, long COVID-19, asthenia |
| first_indexed | 2024-04-13T02:17:51Z |
| format | Article |
| id | doaj.art-40fe532d286c465d93d409688cd1f995 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T02:17:51Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-40fe532d286c465d93d409688cd1f9952022-12-22T03:07:05ZengDove Medical PressInternational Journal of General Medicine1178-70742022-08-01Volume 156645665177490No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19Chan Sui Ko ACandellier AMercier MJoseph CCarette HBasille DLion-Daolio SDevaux SSchmit JLLanoix JPAndrejak CAdrien Chan Sui Ko,1,* Alexandre Candellier,2,* Marie Mercier,3 Cedric Joseph,1 Hortense Carette,3 Damien Basille,3 Sylvie Lion-Daolio,4 Stephanie Devaux,3 Jean-Luc Schmit,1 Jean-Philippe Lanoix,1 Claire Andrejak3 1Department of Infectious Diseases, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 2Department of Nephrology, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 3Department of Pneumology, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France; 4Department of Orthopedy, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France*These authors contributed equally to this workCorrespondence: Adrien Chan Sui Ko, Department of Infectious Diseases, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, 80054, France, Email chansuiko.adrien@chu-amiens.frAbstract: Persistent COVID-19 symptoms may be related to residual inflammation, but no preventive treatment has been evaluated. This study aimed to analyze, in a prospective cohort, whether corticosteroid use in the acute phase of COVID-19 in hospitalized patients may reduce the risk of persistent COVID-19 symptoms. A total of 306 discharged patients, including 112 (36.6%) from the ICU, completed a structured face-to-face assessment 4 months after admission. Of these, 193 patients (63.1%) had at least one persistent symptom, mostly dyspnea (38.9%) and asthenia (37.6%). One-hundred and four patients have received corticosteroids. In multivariable adjusted regression analysis, corticosteroid use was not associated with the presence of at least one symptom (OR=1.00, 95% CI: 0.58– 1.71, p=0.99) or with the number of persistent symptoms (p=0.74). Corticosteroid use remained ineffective when analyzing the ICU subpopulation separately. Our study suggests that corticosteroid use had no impact on persistent symptoms after COVID-19 in discharged patients.Keywords: COVID-19, persistent symptoms, corticosteroid use, long COVID-19, astheniahttps://www.dovepress.com/no-impact-of-corticosteroid-use-during-the-acute-phase-on-persistent-s-peer-reviewed-fulltext-article-IJGMcovid-19persistent symptomscorticosteroid uselong covid-19asthenia |
| spellingShingle | Chan Sui Ko A Candellier A Mercier M Joseph C Carette H Basille D Lion-Daolio S Devaux S Schmit JL Lanoix JP Andrejak C No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 International Journal of General Medicine covid-19 persistent symptoms corticosteroid use long covid-19 asthenia |
| title | No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 |
| title_full | No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 |
| title_fullStr | No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 |
| title_full_unstemmed | No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 |
| title_short | No Impact of Corticosteroid Use During the Acute Phase on Persistent Symptoms Post-COVID-19 |
| title_sort | no impact of corticosteroid use during the acute phase on persistent symptoms post covid 19 |
| topic | covid-19 persistent symptoms corticosteroid use long covid-19 asthenia |
| url | https://www.dovepress.com/no-impact-of-corticosteroid-use-during-the-acute-phase-on-persistent-s-peer-reviewed-fulltext-article-IJGM |
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