Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to dev...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2018-05-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012118775827 |
| _version_ | 1797285390081589248 |
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| author | Yongfeng Zhao PhD Bo Pang PhD Lisa Detering MS Hannah Luehmann MS Miaoxin Yang PhD Kvar Black PhD Deborah Sultan BS Younan Xia PhD Yongjian Liu PhD |
| author_facet | Yongfeng Zhao PhD Bo Pang PhD Lisa Detering MS Hannah Luehmann MS Miaoxin Yang PhD Kvar Black PhD Deborah Sultan BS Younan Xia PhD Yongjian Liu PhD |
| author_sort | Yongfeng Zhao PhD |
| collection | DOAJ |
| description | Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to develop targeted nanoparticles for melanoma theranostics. Method: In this work, gold nanocages (AuNCs) were conjugated with α-melanocyte-stimulating hormone (α-MSH) peptide and radiolabeled with 64 Cu for melanocortin 1 receptor-(MC1R) targeted positron emission tomography (PET) in a mouse B16/F10 melanoma model. Results: Their controlled synthesis and surface chemistry enabled well-defined structure and radiolabeling efficiency. In vivo pharmacokinetic evaluation demonstrated comparable organ distribution between the targeted and nontargeted AuNCs. However, micro-PET/computed tomography (CT) imaging demonstrated specific and improved tumor accumulation via MC1R-mediated delivery. By increasing the coverage density of α-MSH peptide on AuNCs, the tumor delivery efficiency was improved. Conclusion: The controlled synthesis, sensitive PET imaging, and optimal tumor targeting suggested the potential of targeted AuNCs for melanoma theranostics. |
| first_indexed | 2024-03-07T18:02:29Z |
| format | Article |
| id | doaj.art-4100276a9c0040a59c9d398e3a710b69 |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2024-03-07T18:02:29Z |
| publishDate | 2018-05-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-4100276a9c0040a59c9d398e3a710b692024-03-02T10:27:02ZengSAGE PublicationsMolecular Imaging1536-01212018-05-011710.1177/1536012118775827Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission TomographyYongfeng Zhao PhD0Bo Pang PhD1Lisa Detering MS2Hannah Luehmann MS3Miaoxin Yang PhD4Kvar Black PhD5Deborah Sultan BS6Younan Xia PhD7Yongjian Liu PhD8 Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO, USAPurpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to develop targeted nanoparticles for melanoma theranostics. Method: In this work, gold nanocages (AuNCs) were conjugated with α-melanocyte-stimulating hormone (α-MSH) peptide and radiolabeled with 64 Cu for melanocortin 1 receptor-(MC1R) targeted positron emission tomography (PET) in a mouse B16/F10 melanoma model. Results: Their controlled synthesis and surface chemistry enabled well-defined structure and radiolabeling efficiency. In vivo pharmacokinetic evaluation demonstrated comparable organ distribution between the targeted and nontargeted AuNCs. However, micro-PET/computed tomography (CT) imaging demonstrated specific and improved tumor accumulation via MC1R-mediated delivery. By increasing the coverage density of α-MSH peptide on AuNCs, the tumor delivery efficiency was improved. Conclusion: The controlled synthesis, sensitive PET imaging, and optimal tumor targeting suggested the potential of targeted AuNCs for melanoma theranostics.https://doi.org/10.1177/1536012118775827 |
| spellingShingle | Yongfeng Zhao PhD Bo Pang PhD Lisa Detering MS Hannah Luehmann MS Miaoxin Yang PhD Kvar Black PhD Deborah Sultan BS Younan Xia PhD Yongjian Liu PhD Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography Molecular Imaging |
| title | Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography |
| title_full | Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography |
| title_fullStr | Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography |
| title_full_unstemmed | Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography |
| title_short | Melanocortin 1 Receptor Targeted Imaging of Melanoma With Gold Nanocages and Positron Emission Tomography |
| title_sort | melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography |
| url | https://doi.org/10.1177/1536012118775827 |
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