IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma

IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma

IL-27 regulates inflammatory diseases by exerting a pleiotropic impact on immune cells. In cancer, IL-27 restricts tumor growth by acting on tumor cells directly, while its role in the tumor microenvironment is still controversially discussed. To explore IL-27 signaling in the tumor stroma, we used...

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Bibliographic Details
Main Authors: Annika F. Fink, Giorgia Ciliberti, Rüdiger Popp, Evelyn Sirait-Fischer, Ann-Christin Frank, Ingrid Fleming, Divya Sekar, Andreas Weigert, Bernhard Brüne
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
IL-27 cytokine
endothelial cell
mammary cancer
cytokine
angiogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01022/full

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