Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive natural active ingredient from the cannabis plant that has various pharmacological effects, including neuroprotective, antiemetic, anti-in...

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Bibliographic Details
Main Authors: Xiaofan Sun, Lisha Zhou, Yi Wang, Guoliang Deng, Xinran Cao, Bowen Ke, Xiaoqi Wu, Yanhong Gu, Haibo Cheng, Qiang Xu, Qianming Du, Hongqi Chen, Yang Sun
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Journal of Pharmaceutical Analysis
Subjects:
scRNA-seq
scATAC-seq
Cannabidiol
Colorectal cancer
Tumor microenvironment
Macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923000746

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