High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors
Background. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reac...
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MDPI AG
2021-07-01
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| author | Małgorzata Koziarska-Rościszewska Anna Gluba-Brzózka Beata Franczyk Jacek Rysz |
| author_facet | Małgorzata Koziarska-Rościszewska Anna Gluba-Brzózka Beata Franczyk Jacek Rysz |
| author_sort | Małgorzata Koziarska-Rościszewska |
| collection | DOAJ |
| description | Background. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reactive protein (hsCRP) with selected factors—age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D-25(OH)D, cardiovascular diseases (CVD), coronary heart disease, cerebrovascular disease, and hypertension. Results. Statistically significant correlations were found between hsCRP and the following: age (rs = 0.304, <i>p</i> = 0.0000); gender (female) (<i>p</i> = 0.0173); BMI (rs = 0.295, <i>p</i> = 0.0001); waist circumference (rs = 0.250, <i>p</i> = 0.0007); dyslipidemia (<i>p</i> = 0.0159); glycemia (rs = 0.173, <i>p</i> = 0.0207); and significant negative correlations between hsCRP and 25(OH)D (rs = −0.203, <i>p</i> = 0.0065). In patients with CVD, hypertension, diabetes, or visceral obesity, hsCRP was significantly higher than in the subgroup without these disorders. There was a statistically significant relationship between hsCRP and the number of the metabolic syndrome elements (<i>p</i> = 0.0053). Conclusions. The hsCRP test seem to be a simple test that may be used at the primary care level to identify patients at risk of metabolic disorders, CVD, and hypertension. Vitamin D concentration may be a determining factor of systemic inflammation (it may have a modulating effect). |
| first_indexed | 2024-03-10T08:39:53Z |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T08:39:53Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4101e171c3ff425b9ddac4da563b3fe22023-11-22T08:22:13ZengMDPI AGLife2075-17292021-07-0111874210.3390/life11080742High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk FactorsMałgorzata Koziarska-Rościszewska0Anna Gluba-Brzózka1Beata Franczyk2Jacek Rysz3Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego 113, 90-549 Łódź, PolandBackground. Chronic inflammation is considered to be involved in the development of CVD. It is important to find a simple test that enables the identification of patients at risk and that may be used in primary care. The aim of this study is to investigate the associations of high-sensitivity C-reactive protein (hsCRP) with selected factors—age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, vitamin D-25(OH)D, cardiovascular diseases (CVD), coronary heart disease, cerebrovascular disease, and hypertension. Results. Statistically significant correlations were found between hsCRP and the following: age (rs = 0.304, <i>p</i> = 0.0000); gender (female) (<i>p</i> = 0.0173); BMI (rs = 0.295, <i>p</i> = 0.0001); waist circumference (rs = 0.250, <i>p</i> = 0.0007); dyslipidemia (<i>p</i> = 0.0159); glycemia (rs = 0.173, <i>p</i> = 0.0207); and significant negative correlations between hsCRP and 25(OH)D (rs = −0.203, <i>p</i> = 0.0065). In patients with CVD, hypertension, diabetes, or visceral obesity, hsCRP was significantly higher than in the subgroup without these disorders. There was a statistically significant relationship between hsCRP and the number of the metabolic syndrome elements (<i>p</i> = 0.0053). Conclusions. The hsCRP test seem to be a simple test that may be used at the primary care level to identify patients at risk of metabolic disorders, CVD, and hypertension. Vitamin D concentration may be a determining factor of systemic inflammation (it may have a modulating effect).https://www.mdpi.com/2075-1729/11/8/742hsCRPcardiovascular diseasemetabolic syndrome |
| spellingShingle | Małgorzata Koziarska-Rościszewska Anna Gluba-Brzózka Beata Franczyk Jacek Rysz High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors Life hsCRP cardiovascular disease metabolic syndrome |
| title | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
| title_full | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
| title_fullStr | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
| title_full_unstemmed | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
| title_short | High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors |
| title_sort | high sensitivity c reactive protein relationship with metabolic disorders and cardiovascular diseases risk factors |
| topic | hsCRP cardiovascular disease metabolic syndrome |
| url | https://www.mdpi.com/2075-1729/11/8/742 |
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