Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding
Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-06-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/5/6/1466 |
| _version_ | 1818026259077136384 |
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| author | Donald P. Knowles Stephen N. White |
| author_facet | Donald P. Knowles Stephen N. White |
| author_sort | Donald P. Knowles |
| collection | DOAJ |
| description | Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic component in susceptibility to infection by OvLV in sheep. A genetic marker test for susceptibility to OvLV has been developed recently based on the TMEM154 gene with validation data from over 2,800 sheep representing nine cohorts. While no single genotype has been shown to have complete resistance to OvLV, consistent association in thousands of sheep from multiple breeds and management conditions highlight a new strategy for intervention by selective breeding. This genetic marker-assisted selection (MAS) has the potential to be a useful addition to existing viral control measures. Further, the discovery of multiple additional genomic regions associated with susceptibility to or control of OvLV suggests that additional genetic marker tests may be developed to extend the reach of MAS in the future. This review will cover the strengths and limitations of existing data from host genetics as an intervention and outline additional questions for future genetic research in sheep, goats, small ruminant lentiviruses, and their host-pathogen interactions. |
| first_indexed | 2024-12-10T04:29:09Z |
| format | Article |
| id | doaj.art-4102595577df442d8f3c53e9d0aecd58 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-10T04:29:09Z |
| publishDate | 2013-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4102595577df442d8f3c53e9d0aecd582022-12-22T02:02:12ZengMDPI AGViruses1999-49152013-06-01561466149910.3390/v5061466Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective BreedingDonald P. KnowlesStephen N. WhiteSmall ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic component in susceptibility to infection by OvLV in sheep. A genetic marker test for susceptibility to OvLV has been developed recently based on the TMEM154 gene with validation data from over 2,800 sheep representing nine cohorts. While no single genotype has been shown to have complete resistance to OvLV, consistent association in thousands of sheep from multiple breeds and management conditions highlight a new strategy for intervention by selective breeding. This genetic marker-assisted selection (MAS) has the potential to be a useful addition to existing viral control measures. Further, the discovery of multiple additional genomic regions associated with susceptibility to or control of OvLV suggests that additional genetic marker tests may be developed to extend the reach of MAS in the future. This review will cover the strengths and limitations of existing data from host genetics as an intervention and outline additional questions for future genetic research in sheep, goats, small ruminant lentiviruses, and their host-pathogen interactions.http://www.mdpi.com/1999-4915/5/6/1466small ruminant lentivirussusceptibilitymarker-assisted selectionsheepgoatsTMEM154 |
| spellingShingle | Donald P. Knowles Stephen N. White Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding Viruses small ruminant lentivirus susceptibility marker-assisted selection sheep goats TMEM154 |
| title | Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding |
| title_full | Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding |
| title_fullStr | Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding |
| title_full_unstemmed | Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding |
| title_short | Expanding Possibilities for Intervention against Small Ruminant Lentiviruses through Genetic Marker-Assisted Selective Breeding |
| title_sort | expanding possibilities for intervention against small ruminant lentiviruses through genetic marker assisted selective breeding |
| topic | small ruminant lentivirus susceptibility marker-assisted selection sheep goats TMEM154 |
| url | http://www.mdpi.com/1999-4915/5/6/1466 |
| work_keys_str_mv | AT donaldpknowles expandingpossibilitiesforinterventionagainstsmallruminantlentivirusesthroughgeneticmarkerassistedselectivebreeding AT stephennwhite expandingpossibilitiesforinterventionagainstsmallruminantlentivirusesthroughgeneticmarkerassistedselectivebreeding |