Deciphering the molecular profile of plaques, memory decline and neuron-loss in two mouse models for Alzheimer’s disease by deep sequencing

Deciphering the molecular profile of plaques, memory decline and neuron-loss in two mouse models for Alzheimer’s disease by deep sequencing

One of the central research questions on the etiology of Alzheimer’s disease (AD) is the elucidation of the molecular signatures triggered by the amyloid cascade of pathological events. Next generation sequencing allows the identification of genes involved in disease processes in an unbiased manner....

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Bibliographic Details
Main Authors: Yvonne eBouter, Tim eKacprowski, Robert eWeissmann, Katharina eDietrich, Henning eBorgers, Andreas eBrauß, Christian eSperling, Oliver eWirths, Mario eAlbrecht, Lars R. Jensen, Andreas W. Kuss, Thomas A Bayer
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Transcriptome
Fear conditioning
RNA-Seq
Deep sequencing
Morris water maze
neuron loss
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00075/full

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