Stability of an aluminum salt-adjuvanted protein D-conjugated pneumococcal vaccine after exposure to subzero temperatures

Stability of an aluminum salt-adjuvanted protein D-conjugated pneumococcal vaccine after exposure to subzero temperatures

Accidental exposure of a vaccine containing an aluminum-salt adjuvant to temperatures below 0°C in the cold chain can lead to freeze damage. Our study evaluated the potential for freeze damage in a licensed aluminum-salt-containing protein-D-conjugated pneumococcal vaccine (PHiD-CV; Synflorix, GSK)...

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Bibliographic Details
Main Authors: Juliette Fortpied, Florence Wauters, Christelle Rochart, Philippe Hermand, Bernard Hoet, Nicolas Moniotte, Ivo Vojtek
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
pneumococcal conjugate vaccine
polysaccharide
alum
aluminum salt
shake test
vaccine thermosensitivity
cold chain
subzero temperature
freezing
vaccine thermostability
Online Access:http://dx.doi.org/10.1080/21645515.2017.1421878

Internet

http://dx.doi.org/10.1080/21645515.2017.1421878

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