Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management
<p>Abstract</p> <p>Effective treatment of venous thromboembolism (VTE) strikes a balance between prevention of recurrence and bleeding complications. The current standard of care is heparin followed by a vitamin K antagonist such as warfarin. However, this option is not without its...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-12-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | http://www.thrombosisjournal.com/content/10/1/24 |
| _version_ | 1828744932325588992 |
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| author | Hass Bastian Pooley Jayne Harrington Adrian E Clemens Andreas Feuring Martin |
| author_facet | Hass Bastian Pooley Jayne Harrington Adrian E Clemens Andreas Feuring Martin |
| author_sort | Hass Bastian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Effective treatment of venous thromboembolism (VTE) strikes a balance between prevention of recurrence and bleeding complications. The current standard of care is heparin followed by a vitamin K antagonist such as warfarin. However, this option is not without its limitations, as the anticoagulant effect of warfarin is associated with high inter- and intra-patient variability and patients must be regularly monitored to ensure that anticoagulation is within the narrow target therapeutic range. Several novel oral anticoagulant agents are in the advanced stages of development for VTE treatment, some of which are given after an initial period of heparin treatment, in line with current practice, while others switch from high to low doses after the initial phase of treatment. In this review we assess the critical considerations for treating VTE in light of emerging clinical data for new oral agents and discuss the merits of novel treatment regimens for patients who have experienced an episode of deep vein thrombosis or pulmonary embolism.</p> |
| first_indexed | 2024-04-14T03:53:25Z |
| format | Article |
| id | doaj.art-4103e1990e294e5dbb9b86e3526da34c |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-04-14T03:53:25Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-4103e1990e294e5dbb9b86e3526da34c2022-12-22T02:13:56ZengBMCThrombosis Journal1477-95602012-12-011012410.1186/1477-9560-10-24Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant managementHass BastianPooley JayneHarrington Adrian EClemens AndreasFeuring Martin<p>Abstract</p> <p>Effective treatment of venous thromboembolism (VTE) strikes a balance between prevention of recurrence and bleeding complications. The current standard of care is heparin followed by a vitamin K antagonist such as warfarin. However, this option is not without its limitations, as the anticoagulant effect of warfarin is associated with high inter- and intra-patient variability and patients must be regularly monitored to ensure that anticoagulation is within the narrow target therapeutic range. Several novel oral anticoagulant agents are in the advanced stages of development for VTE treatment, some of which are given after an initial period of heparin treatment, in line with current practice, while others switch from high to low doses after the initial phase of treatment. In this review we assess the critical considerations for treating VTE in light of emerging clinical data for new oral agents and discuss the merits of novel treatment regimens for patients who have experienced an episode of deep vein thrombosis or pulmonary embolism.</p>http://www.thrombosisjournal.com/content/10/1/24Venous thromboembolismAnticoagulantsVitamin K antagonistsHeparinRecurrenceBleeding |
| spellingShingle | Hass Bastian Pooley Jayne Harrington Adrian E Clemens Andreas Feuring Martin Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management Thrombosis Journal Venous thromboembolism Anticoagulants Vitamin K antagonists Heparin Recurrence Bleeding |
| title | Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| title_full | Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| title_fullStr | Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| title_full_unstemmed | Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| title_short | Treatment of venous thromboembolism – effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| title_sort | treatment of venous thromboembolism effects of different therapeutic strategies on bleeding and recurrence rates and considerations for future anticoagulant management |
| topic | Venous thromboembolism Anticoagulants Vitamin K antagonists Heparin Recurrence Bleeding |
| url | http://www.thrombosisjournal.com/content/10/1/24 |
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