Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19
Abstract Arterial hypertension represented one of the most common comorbidities in patients with COVID‐19. However, the impact of hypertension on outcome in COVID‐19 patients is not clear. Close connections between inflammation and blood pressure (BP) have been described, and inflammation plays a ke...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-02-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14137 |
| _version_ | 1797645152410402816 |
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| author | Jacques Amar Nicolas Touront Antoine M. Ciron Caroline Pendaries |
| author_facet | Jacques Amar Nicolas Touront Antoine M. Ciron Caroline Pendaries |
| author_sort | Jacques Amar |
| collection | DOAJ |
| description | Abstract Arterial hypertension represented one of the most common comorbidities in patients with COVID‐19. However, the impact of hypertension on outcome in COVID‐19 patients is not clear. Close connections between inflammation and blood pressure (BP) have been described, and inflammation plays a key role in the outcome for patients with COVID‐19. Whether hypertension impairs the relationship between inflammation, BP, and outcomes in this context is not known. The aim of this study was to examine the effects of the interactions between inflammation and hypertension status on BP and clinical outcome in patients hospitalized with COVID‐19. We designed a retrospective study in 129 patients hospitalized with COVID‐19 at Toulouse University Hospital. The hospital outcome was admission to the intensive care unit or death. The inflammatory markers were blood C‐reactive protein level (CRP), neutrophil to lymphocyte, and platelet to lymphocyte ratios. We identified strong correlations between CRP (P < .01) and the other inflammatory markers recorded on admission (P < .001) with mean BP within 3 days after admission in normotensive patients, whereas these correlations were absent in patients with hypertension. Also, we observed after multivariate adjustment (P < .05) that CRP level predicted a worse prognosis in hypertensive patients (relative risk 2.52; 95% confidence intervals [1.03‐ 6.17]; P = .04), whereas CRP was not predictive of outcome in patients without hypertension. In conclusion, the study revealed that in COVID‐19 patients, hypertension impairs the relationship between inflammation and BP and interacts with inflammation to affect prognosis. These findings provide insights that could explain the relationship between hypertension and outcomes in COVID‐19 patients. |
| first_indexed | 2024-03-11T14:42:00Z |
| format | Article |
| id | doaj.art-4104221c769b4bb88f571edbc5f947f8 |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:42:00Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-4104221c769b4bb88f571edbc5f947f82023-10-30T13:30:44ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762021-02-0123223824410.1111/jch.14137Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19Jacques Amar0Nicolas Touront1Antoine M. Ciron2Caroline Pendaries3Department of Arterial Hypertension Toulouse University III Toulouse FranceDepartment of Arterial Hypertension Toulouse University III Toulouse FranceDepartment of Arterial Hypertension Toulouse University III Toulouse FranceDepartment of Arterial Hypertension Toulouse University III Toulouse FranceAbstract Arterial hypertension represented one of the most common comorbidities in patients with COVID‐19. However, the impact of hypertension on outcome in COVID‐19 patients is not clear. Close connections between inflammation and blood pressure (BP) have been described, and inflammation plays a key role in the outcome for patients with COVID‐19. Whether hypertension impairs the relationship between inflammation, BP, and outcomes in this context is not known. The aim of this study was to examine the effects of the interactions between inflammation and hypertension status on BP and clinical outcome in patients hospitalized with COVID‐19. We designed a retrospective study in 129 patients hospitalized with COVID‐19 at Toulouse University Hospital. The hospital outcome was admission to the intensive care unit or death. The inflammatory markers were blood C‐reactive protein level (CRP), neutrophil to lymphocyte, and platelet to lymphocyte ratios. We identified strong correlations between CRP (P < .01) and the other inflammatory markers recorded on admission (P < .001) with mean BP within 3 days after admission in normotensive patients, whereas these correlations were absent in patients with hypertension. Also, we observed after multivariate adjustment (P < .05) that CRP level predicted a worse prognosis in hypertensive patients (relative risk 2.52; 95% confidence intervals [1.03‐ 6.17]; P = .04), whereas CRP was not predictive of outcome in patients without hypertension. In conclusion, the study revealed that in COVID‐19 patients, hypertension impairs the relationship between inflammation and BP and interacts with inflammation to affect prognosis. These findings provide insights that could explain the relationship between hypertension and outcomes in COVID‐19 patients.https://doi.org/10.1111/jch.14137COVID‐19C‐reactive proteinhypertensioninflammation |
| spellingShingle | Jacques Amar Nicolas Touront Antoine M. Ciron Caroline Pendaries Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 The Journal of Clinical Hypertension COVID‐19 C‐reactive protein hypertension inflammation |
| title | Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 |
| title_full | Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 |
| title_fullStr | Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 |
| title_full_unstemmed | Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 |
| title_short | Interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with COVID‐19 |
| title_sort | interactions between hypertension and inflammatory tone and the effect on blood pressure and outcomes in patients with covid 19 |
| topic | COVID‐19 C‐reactive protein hypertension inflammation |
| url | https://doi.org/10.1111/jch.14137 |
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