Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates
<i>Cyclospora cayetanensis</i> is an enigmatic human parasite that sickens thousands of people worldwide. The scarcity of research material and lack of any animal model or cell culture system slows research, denying the produce industry, epidemiologists, and regulatory agencies of tools...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/10/1977 |
| _version_ | 1797471062117580800 |
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| author | Matthew S. Tucker Asis Khan Mark C. Jenkins Jitender P. Dubey Benjamin M. Rosenthal |
| author_facet | Matthew S. Tucker Asis Khan Mark C. Jenkins Jitender P. Dubey Benjamin M. Rosenthal |
| author_sort | Matthew S. Tucker |
| collection | DOAJ |
| description | <i>Cyclospora cayetanensis</i> is an enigmatic human parasite that sickens thousands of people worldwide. The scarcity of research material and lack of any animal model or cell culture system slows research, denying the produce industry, epidemiologists, and regulatory agencies of tools that might aid diagnosis, risk assessment, and risk abatement. Fortunately, related species offer a strong foundation when used as surrogates to study parasites of this type. Species of <i>Eimeria</i> lend themselves especially well as surrogates for <i>C. cayetanensis.</i> Those <i>Eimeria</i> that infect poultry can be produced in abundance, share many biological features with <i>Cyclospora</i>, pose no risk to the health of researchers, and can be studied in their natural hosts. Here, we overview the actual and potential uses of such surrogates to advance understanding of <i>C. cayetanensis</i> biology, diagnostics, control, and genomics, focusing on opportunities to improve prevention, surveillance, risk assessment, and risk reduction. Studying <i>Eimeria</i> surrogates accelerates progress, closing important research gaps and refining promising tools for producers and food safety regulators to monitor and ameliorate the food safety risks imposed by this emerging, enigmatic parasite. |
| first_indexed | 2024-03-09T19:44:16Z |
| format | Article |
| id | doaj.art-4104ec31ff934cdc9f9e0dbe85b150cd |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T19:44:16Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-4104ec31ff934cdc9f9e0dbe85b150cd2023-11-24T01:26:27ZengMDPI AGMicroorganisms2076-26072022-10-011010197710.3390/microorganisms10101977Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> SurrogatesMatthew S. Tucker0Asis Khan1Mark C. Jenkins2Jitender P. Dubey3Benjamin M. Rosenthal4Animal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USAAnimal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USAAnimal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USAAnimal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USAAnimal Parasitic Disease Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, BARC-East, Beltsville, MD 20705, USA<i>Cyclospora cayetanensis</i> is an enigmatic human parasite that sickens thousands of people worldwide. The scarcity of research material and lack of any animal model or cell culture system slows research, denying the produce industry, epidemiologists, and regulatory agencies of tools that might aid diagnosis, risk assessment, and risk abatement. Fortunately, related species offer a strong foundation when used as surrogates to study parasites of this type. Species of <i>Eimeria</i> lend themselves especially well as surrogates for <i>C. cayetanensis.</i> Those <i>Eimeria</i> that infect poultry can be produced in abundance, share many biological features with <i>Cyclospora</i>, pose no risk to the health of researchers, and can be studied in their natural hosts. Here, we overview the actual and potential uses of such surrogates to advance understanding of <i>C. cayetanensis</i> biology, diagnostics, control, and genomics, focusing on opportunities to improve prevention, surveillance, risk assessment, and risk reduction. Studying <i>Eimeria</i> surrogates accelerates progress, closing important research gaps and refining promising tools for producers and food safety regulators to monitor and ameliorate the food safety risks imposed by this emerging, enigmatic parasite.https://www.mdpi.com/2076-2607/10/10/1977<i>Eimeria</i><i>Cyclospora</i>coccidiasurrogatesdetectioncontrol |
| spellingShingle | Matthew S. Tucker Asis Khan Mark C. Jenkins Jitender P. Dubey Benjamin M. Rosenthal Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates Microorganisms <i>Eimeria</i> <i>Cyclospora</i> coccidia surrogates detection control |
| title | Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates |
| title_full | Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates |
| title_fullStr | Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates |
| title_full_unstemmed | Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates |
| title_short | Hastening Progress in <i>Cyclospora</i> Requires Studying <i>Eimeria</i> Surrogates |
| title_sort | hastening progress in i cyclospora i requires studying i eimeria i surrogates |
| topic | <i>Eimeria</i> <i>Cyclospora</i> coccidia surrogates detection control |
| url | https://www.mdpi.com/2076-2607/10/10/1977 |
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