PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers
Sarcoidosis is a multi-system inflammatory disease characterized by the development of inflammation and noncaseating granulomas that can involve nearly every organ system, with a predilection for the pulmonary system. Cardiac involvement of sarcoidosis (CS) occurs in up to 70% of cases, and accounts...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/12/1286 |
| _version_ | 1797501566492606464 |
|---|---|
| author | Petar Saric Kathleen A. Young Martin Rodriguez-Porcel Panithaya Chareonthaitawee |
| author_facet | Petar Saric Kathleen A. Young Martin Rodriguez-Porcel Panithaya Chareonthaitawee |
| author_sort | Petar Saric |
| collection | DOAJ |
| description | Sarcoidosis is a multi-system inflammatory disease characterized by the development of inflammation and noncaseating granulomas that can involve nearly every organ system, with a predilection for the pulmonary system. Cardiac involvement of sarcoidosis (CS) occurs in up to 70% of cases, and accounts for a significant share of sarcoid-related mortality. The clinical presentation of CS can range from absence of symptoms to conduction abnormalities, heart failure, arrhythmias, valvular disease, and sudden cardiac death. Given the significant morbidity and mortality associated with CS, timely diagnosis is important. Traditional imaging modalities and histologic evaluation by endomyocardial biopsy often provide a low diagnostic yield. Cardiac positron emission tomography (PET) has emerged as a leading advanced imaging modality for the diagnosis and management of CS. This review article will summarize several aspects of the current use of PET in CS, including indications for use, patient preparation, image acquisition and interpretation, diagnostic and prognostic performance, and evaluation of treatment response. Additionally, this review will discuss novel PET radiotracers currently under study or of potential interest in CS. |
| first_indexed | 2024-03-10T03:20:17Z |
| format | Article |
| id | doaj.art-41073541ab00432f9b68e3e8b55606f0 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:20:17Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-41073541ab00432f9b68e3e8b55606f02023-11-23T10:03:35ZengMDPI AGPharmaceuticals1424-82472021-12-011412128610.3390/ph14121286PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET TracersPetar Saric0Kathleen A. Young1Martin Rodriguez-Porcel2Panithaya Chareonthaitawee3Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USADepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USADepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USADepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USASarcoidosis is a multi-system inflammatory disease characterized by the development of inflammation and noncaseating granulomas that can involve nearly every organ system, with a predilection for the pulmonary system. Cardiac involvement of sarcoidosis (CS) occurs in up to 70% of cases, and accounts for a significant share of sarcoid-related mortality. The clinical presentation of CS can range from absence of symptoms to conduction abnormalities, heart failure, arrhythmias, valvular disease, and sudden cardiac death. Given the significant morbidity and mortality associated with CS, timely diagnosis is important. Traditional imaging modalities and histologic evaluation by endomyocardial biopsy often provide a low diagnostic yield. Cardiac positron emission tomography (PET) has emerged as a leading advanced imaging modality for the diagnosis and management of CS. This review article will summarize several aspects of the current use of PET in CS, including indications for use, patient preparation, image acquisition and interpretation, diagnostic and prognostic performance, and evaluation of treatment response. Additionally, this review will discuss novel PET radiotracers currently under study or of potential interest in CS.https://www.mdpi.com/1424-8247/14/12/1286cardiac sarcoidosispositron emission tomographyfluorodeoxyglucosesomatostatin analogsfluorothymidinehypoxia tracers |
| spellingShingle | Petar Saric Kathleen A. Young Martin Rodriguez-Porcel Panithaya Chareonthaitawee PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers Pharmaceuticals cardiac sarcoidosis positron emission tomography fluorodeoxyglucose somatostatin analogs fluorothymidine hypoxia tracers |
| title | PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers |
| title_full | PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers |
| title_fullStr | PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers |
| title_full_unstemmed | PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers |
| title_short | PET Imaging in Cardiac Sarcoidosis: A Narrative Review with Focus on Novel PET Tracers |
| title_sort | pet imaging in cardiac sarcoidosis a narrative review with focus on novel pet tracers |
| topic | cardiac sarcoidosis positron emission tomography fluorodeoxyglucose somatostatin analogs fluorothymidine hypoxia tracers |
| url | https://www.mdpi.com/1424-8247/14/12/1286 |
| work_keys_str_mv | AT petarsaric petimagingincardiacsarcoidosisanarrativereviewwithfocusonnovelpettracers AT kathleenayoung petimagingincardiacsarcoidosisanarrativereviewwithfocusonnovelpettracers AT martinrodriguezporcel petimagingincardiacsarcoidosisanarrativereviewwithfocusonnovelpettracers AT panithayachareonthaitawee petimagingincardiacsarcoidosisanarrativereviewwithfocusonnovelpettracers |