Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men
Rationale: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretio...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2019-12-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://doi.org/10.1530/EC-19-0408 |
| _version_ | 1818393949407019008 |
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| author | Charlotte Janus Dorte Vistisen Hanan Amadid Daniel R Witte Torsten Lauritzen Søren Brage Anne-Louise Bjerregaard Torben Hansen Jens J Holst Marit E Jørgensen Oluf Pedersen Kristine Færch Signe S Torekov |
| author_facet | Charlotte Janus Dorte Vistisen Hanan Amadid Daniel R Witte Torsten Lauritzen Søren Brage Anne-Louise Bjerregaard Torben Hansen Jens J Holst Marit E Jørgensen Oluf Pedersen Kristine Færch Signe S Torekov |
| author_sort | Charlotte Janus |
| collection | DOAJ |
| description | Rationale: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.
Methods: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (s.d.) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responses were measured using validated radioimmunoassay. PA was measured using 7-day combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE; kJ/kg/day) and fractions of time spent in activity intensities (h/day) were calculated. Cardiorespiratory fitness (CRF; mL O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, w ere evaluated by linear regression analysis.
Results: In 703 men, fasting GLP-1 concentrations were 20% lower (95% CI: −33; −3%, P = 0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1–2% lower fasting GLP-1 (P = 0.01). For every hour of moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1; 33%, PrAUC0-30 = 0.04) and 20% greater at full response (3; 40%, PrAUC0-120 = 0.02). No associations were found in women who performed PA 22 min/day vs 32 min/day for men.
Conclusion: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA. |
| first_indexed | 2024-12-14T05:53:26Z |
| format | Article |
| id | doaj.art-41090cf018364d4faa48a1639e5a6afb |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T05:53:26Z |
| publishDate | 2019-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-41090cf018364d4faa48a1639e5a6afb2022-12-21T23:14:39ZengBioscientificaEndocrine Connections2049-36142049-36142019-12-0181216071617https://doi.org/10.1530/EC-19-0408Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in menCharlotte Janus0Dorte Vistisen1Hanan Amadid2Daniel R Witte3Torsten Lauritzen4Søren Brage5Anne-Louise Bjerregaard6Torben Hansen7Jens J Holst8Marit E Jørgensen9Oluf Pedersen10Kristine Færch11Signe S Torekov12Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Diabetes Academy, Odense University Hospital, Odense, DenmarkSteno Diabetes Center Copenhagen, Gentofte, DenmarkSteno Diabetes Center Copenhagen, Gentofte, Denmark; Department of Public Health, Research Unit of Epidemiology, Aarhus University, Aarhus, DenmarkDanish Diabetes Academy, Odense University Hospital, Odense, Denmark; Department of Public Health, Research Unit of Epidemiology, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus, DenmarkDepartment of Public Health, Research Unit of Epidemiology, Aarhus University, Aarhus, DenmarkMRC Epidemiology Unit, University of Cambridge, Cambridge, UKDepartment of Public Health, Research Unit of Epidemiology, Aarhus University, Aarhus, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkSteno Diabetes Center Copenhagen, Gentofte, Denmark; National Institute of Public Health, University of Southern Denmark, Odense, Denmark Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkRationale: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals. Methods: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (s.d.) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responses were measured using validated radioimmunoassay. PA was measured using 7-day combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE; kJ/kg/day) and fractions of time spent in activity intensities (h/day) were calculated. Cardiorespiratory fitness (CRF; mL O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, w ere evaluated by linear regression analysis. Results: In 703 men, fasting GLP-1 concentrations were 20% lower (95% CI: −33; −3%, P = 0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1–2% lower fasting GLP-1 (P = 0.01). For every hour of moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1; 33%, PrAUC0-30 = 0.04) and 20% greater at full response (3; 40%, PrAUC0-120 = 0.02). No associations were found in women who performed PA 22 min/day vs 32 min/day for men. Conclusion: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.https://doi.org/10.1530/EC-19-0408habitual physical activityglucagon-like peptide-1 (glp-1)overweightprediabetesexercise |
| spellingShingle | Charlotte Janus Dorte Vistisen Hanan Amadid Daniel R Witte Torsten Lauritzen Søren Brage Anne-Louise Bjerregaard Torben Hansen Jens J Holst Marit E Jørgensen Oluf Pedersen Kristine Færch Signe S Torekov Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men Endocrine Connections habitual physical activity glucagon-like peptide-1 (glp-1) overweight prediabetes exercise |
| title | Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men |
| title_full | Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men |
| title_fullStr | Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men |
| title_full_unstemmed | Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men |
| title_short | Habitual physical activity is associated with lower fasting and greater glucose-induced GLP-1 response in men |
| title_sort | habitual physical activity is associated with lower fasting and greater glucose induced glp 1 response in men |
| topic | habitual physical activity glucagon-like peptide-1 (glp-1) overweight prediabetes exercise |
| url | https://doi.org/10.1530/EC-19-0408 |
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