Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine

Rhodium-Catalyzed Ortho-Vinylation of 2-Arylpyridines and Its Application in the Total Synthesis of Palmatine

An efficient protocol by Rh-catalyzed direct C–H vinylation of 2-arylpyridines with a commercially available and air-stable potassium vinyl donor has been developed. This method affords the corresponding pyridinyl styrene derivative with moderate to excellent yields under mild conditions, which is e...

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Bibliographic Details
Main Authors: Shan Lv, Ruifang Nie, Lingmei Guo, Yang Zheng, Yanzhao Liu, Li Guo, Yong Wu
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2020-06-01
Series:Pharmaceutical Fronts
Subjects:
rhodium-catalyzed
c–h activation
ortho-vinylation
potassium vinyltrifluoroborate
palmatine
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1712998

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