An attempt to induce an immunomodulatory effect in rowers with spirulina extract
Background The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response can be modulated by supplementation with spirulina (cyanobacterium Spirulina platensis). Method The double-blind study inclu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-02-01
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| Series: | Journal of the International Society of Sports Nutrition |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1186/s12970-018-0213-3 |
| _version_ | 1797685002958274560 |
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| author | Artur Juszkiewicz Piotr Basta Elżbieta Petriczko Bogusław Machaliński Jerzy Trzeciak Karolina Łuczkowska Anna Skarpańska-Stejnborn |
| author_facet | Artur Juszkiewicz Piotr Basta Elżbieta Petriczko Bogusław Machaliński Jerzy Trzeciak Karolina Łuczkowska Anna Skarpańska-Stejnborn |
| author_sort | Artur Juszkiewicz |
| collection | DOAJ |
| description | Background The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response can be modulated by supplementation with spirulina (cyanobacterium Spirulina platensis). Method The double-blind study included 19 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 10), receiving 1500 mg of spirulina extract for 6 weeks, or to the placebo group (n = 9). The participants performed a 2000-m test on a rowing ergometer at the beginning (1st examination) and at the end of the supplementation period (2nd examination). Blood samples were obtained from the antecubital vein prior to each exercise test, 1 min after completing the test, and after a 24-h recovery period. Subpopulations of T regulatory lymphocytes (Tregs) [CD4+/CD25+/CD127-], cytotoxic lymphocytes (CTLs) [CD8+/TCRαβ+], natural killer (NK) cells [CD3-/CD16+/CD56+] and TCRδγ-positive (Tδγ) cells were determined by means of flow cytometry. Results On the 2nd examination, athletes from the supplemented group showed neither a post-exercise increase in Treg count nor a post-recovery decrease in Tδγ cell count (both observed in the placebo group), and presented with significantly lower values of Treg/CTL prior to and after the exercise. During the same examination, rowers from the placebo group showed a significant post-recovery increase in Treg/(NK + Tδγ + CTL) ratio, which was absent in the supplemented group. Conclusion The results of this study imply that supplementation with spirulina extract may protect athletes against a deficit in immune function (especially, anti-infectious function) associated with strenuous exercise, and may cause a beneficial shift in “overtraining threshold” preventing a radical deterioration of immunity. |
| first_indexed | 2024-03-12T00:38:03Z |
| format | Article |
| id | doaj.art-410c239b5d8c45cd8ca9da8be21d1964 |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-12T00:38:03Z |
| publishDate | 2018-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-410c239b5d8c45cd8ca9da8be21d19642023-09-15T09:19:29ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832018-02-0115110.1186/s12970-018-0213-312130027An attempt to induce an immunomodulatory effect in rowers with spirulina extractArtur Juszkiewicz0Piotr Basta1Elżbieta Petriczko2Bogusław Machaliński3Jerzy Trzeciak4Karolina Łuczkowska5Anna Skarpańska-Stejnborn6Department of Morphological and Health SciencesDepartment of Water SportsDepartment of Pediatrics, Endocrinology, Diabetology, Metabolic Disorders and Cardiology of Developmental AgeDepartment of General PathologyDepartment of Morphological and Health SciencesDepartment of General PathologyDepartment of Morphological and Health SciencesBackground The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response can be modulated by supplementation with spirulina (cyanobacterium Spirulina platensis). Method The double-blind study included 19 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 10), receiving 1500 mg of spirulina extract for 6 weeks, or to the placebo group (n = 9). The participants performed a 2000-m test on a rowing ergometer at the beginning (1st examination) and at the end of the supplementation period (2nd examination). Blood samples were obtained from the antecubital vein prior to each exercise test, 1 min after completing the test, and after a 24-h recovery period. Subpopulations of T regulatory lymphocytes (Tregs) [CD4+/CD25+/CD127-], cytotoxic lymphocytes (CTLs) [CD8+/TCRαβ+], natural killer (NK) cells [CD3-/CD16+/CD56+] and TCRδγ-positive (Tδγ) cells were determined by means of flow cytometry. Results On the 2nd examination, athletes from the supplemented group showed neither a post-exercise increase in Treg count nor a post-recovery decrease in Tδγ cell count (both observed in the placebo group), and presented with significantly lower values of Treg/CTL prior to and after the exercise. During the same examination, rowers from the placebo group showed a significant post-recovery increase in Treg/(NK + Tδγ + CTL) ratio, which was absent in the supplemented group. Conclusion The results of this study imply that supplementation with spirulina extract may protect athletes against a deficit in immune function (especially, anti-infectious function) associated with strenuous exercise, and may cause a beneficial shift in “overtraining threshold” preventing a radical deterioration of immunity.http://dx.doi.org/10.1186/s12970-018-0213-3spirulinasupplementationflow cytometryinflammationstrenuous exerciserowers |
| spellingShingle | Artur Juszkiewicz Piotr Basta Elżbieta Petriczko Bogusław Machaliński Jerzy Trzeciak Karolina Łuczkowska Anna Skarpańska-Stejnborn An attempt to induce an immunomodulatory effect in rowers with spirulina extract Journal of the International Society of Sports Nutrition spirulina supplementation flow cytometry inflammation strenuous exercise rowers |
| title | An attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| title_full | An attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| title_fullStr | An attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| title_full_unstemmed | An attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| title_short | An attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| title_sort | attempt to induce an immunomodulatory effect in rowers with spirulina extract |
| topic | spirulina supplementation flow cytometry inflammation strenuous exercise rowers |
| url | http://dx.doi.org/10.1186/s12970-018-0213-3 |
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