FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS
During the chemotherapy, frequency and characteristics of adverse reactions to second line anti-tuberculosis drugs in 324 patients ill with multiple drug resistant tuberculosis were investigated. The majority of patients (319 - 98.4%) had various adverse reactions to second line anti-tuberculosis dr...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-11-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1054 |
| _version_ | 1826563101016719360 |
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| author | A. A. Toktogonova |
| author_facet | A. A. Toktogonova |
| author_sort | A. A. Toktogonova |
| collection | DOAJ |
| description | During the chemotherapy, frequency and characteristics of adverse reactions to second line anti-tuberculosis drugs in 324 patients ill with multiple drug resistant tuberculosis were investigated. The majority of patients (319 - 98.4%) had various adverse reactions to second line anti-tuberculosis drugs.Adverse reactions caused by one or two drugs provided no negative impact on treatment efficiency. As the number of poorly tolerated drugs increased, the level of favorable treatment outcomes went down, whereby the significant confident correlation was observed between adverse outcomes and poor tolerance of 3 and more anti-tuberculosis drugs p = 0.000, r = +> 0.9. There was doubtful correlation observed between poor tolerance anti-tuberculosis drugs and cases deaths (p > 0.05, r = +> 0.3). The doubtful correlation was also observed between cases of lost from treatment and poor tolerance of anti-tuberculosis drugs, p > 0.05, r = +> 0.3. |
| first_indexed | 2024-03-12T05:05:34Z |
| format | Article |
| id | doaj.art-410e18add63b4d66828f238ec070af16 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2025-03-14T09:58:36Z |
| publishDate | 2017-11-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-410e18add63b4d66828f238ec070af162025-03-02T11:22:27ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-11-019510636710.21292/2075-1230-2017-95-10-63-671054FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSISA. A. Toktogonova0National Phthisiology CenterDuring the chemotherapy, frequency and characteristics of adverse reactions to second line anti-tuberculosis drugs in 324 patients ill with multiple drug resistant tuberculosis were investigated. The majority of patients (319 - 98.4%) had various adverse reactions to second line anti-tuberculosis drugs.Adverse reactions caused by one or two drugs provided no negative impact on treatment efficiency. As the number of poorly tolerated drugs increased, the level of favorable treatment outcomes went down, whereby the significant confident correlation was observed between adverse outcomes and poor tolerance of 3 and more anti-tuberculosis drugs p = 0.000, r = +> 0.9. There was doubtful correlation observed between poor tolerance anti-tuberculosis drugs and cases deaths (p > 0.05, r = +> 0.3). The doubtful correlation was also observed between cases of lost from treatment and poor tolerance of anti-tuberculosis drugs, p > 0.05, r = +> 0.3.https://www.tibl-journal.com/jour/article/view/1054multiple drug resistance of tuberculous mycobacteriaintolerance of second line anti-tuberculosis drugsadverse reactions to second line anti-tuberculosis drugs |
| spellingShingle | A. A. Toktogonova FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS Туберкулез и болезни лёгких multiple drug resistance of tuberculous mycobacteria intolerance of second line anti-tuberculosis drugs adverse reactions to second line anti-tuberculosis drugs |
| title | FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS |
| title_full | FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS |
| title_fullStr | FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS |
| title_full_unstemmed | FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS |
| title_short | FREQUENCY AND CHARACTERISTICS OF ADVERSE REACTIONS TO SECOND LINE ANTI-TUBERCULOSIS DRUGS IN THOSE ILL WITH MULTIPLE DRUG RESISTANT TUBERCULOSIS |
| title_sort | frequency and characteristics of adverse reactions to second line anti tuberculosis drugs in those ill with multiple drug resistant tuberculosis |
| topic | multiple drug resistance of tuberculous mycobacteria intolerance of second line anti-tuberculosis drugs adverse reactions to second line anti-tuberculosis drugs |
| url | https://www.tibl-journal.com/jour/article/view/1054 |
| work_keys_str_mv | AT aatoktogonova frequencyandcharacteristicsofadversereactionstosecondlineantituberculosisdrugsinthoseillwithmultipledrugresistanttuberculosis |