Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia
Xueyao Li, Xiuzhen Tong Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Xiuzhen Tong, Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, 58 Second Zhongshan Road, Guangzhou, CPZN 51008...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/role-of-measurable-residual-disease-in-older-adult-acute-myeloid-leuke-peer-reviewed-fulltext-article-CIA |
| _version_ | 1827910416620060672 |
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| author | Li X Tong X |
| author_facet | Li X Tong X |
| author_sort | Li X |
| collection | DOAJ |
| description | Xueyao Li, Xiuzhen Tong Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Xiuzhen Tong, Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, 58 Second Zhongshan Road, Guangzhou, CPZN 510080, People’s Republic of China, Email tongxz05@163.comAbstract: There is overwhelming evidence indicating that the use of measurable residual disease (MRD) as a biomarker provides critical prognostic information and that MRD may have a role in directing postremission decisions. There are a variety of assays for MRD assessment, such as multiparameter flow cytometry and molecular assessment of MRD, which present different characteristics in patients older than 60 years of age. Due to multiple reasons related to age, the progress of older adult AML patients is rarely investigated, especially with respect to MRD. In this review, we will clarify the characteristics of different assays for assessing MRD, focusing on its role as a risk-stratification biomarker to predict prognostic information and its role in optimal postremission therapy among older adult AML patients. These characteristics also provide guidance regarding the potential to apply personalized medicine in older adult AML patients.Keywords: detection method, risk-stratification marker, postremission decisions, personalized medicine |
| first_indexed | 2024-03-13T01:50:23Z |
| format | Article |
| id | doaj.art-410e1943c7a645208900e446261a0cf1 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-03-13T01:50:23Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-410e1943c7a645208900e446261a0cf12023-07-02T19:49:15ZengDove Medical PressClinical Interventions in Aging1178-19982023-06-01Volume 1892193184267Role of Measurable Residual Disease in Older Adult Acute Myeloid LeukemiaLi XTong XXueyao Li, Xiuzhen Tong Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Xiuzhen Tong, Department of Hematology, The First Affiliated Hospital, Sun Yat-sen University, 58 Second Zhongshan Road, Guangzhou, CPZN 510080, People’s Republic of China, Email tongxz05@163.comAbstract: There is overwhelming evidence indicating that the use of measurable residual disease (MRD) as a biomarker provides critical prognostic information and that MRD may have a role in directing postremission decisions. There are a variety of assays for MRD assessment, such as multiparameter flow cytometry and molecular assessment of MRD, which present different characteristics in patients older than 60 years of age. Due to multiple reasons related to age, the progress of older adult AML patients is rarely investigated, especially with respect to MRD. In this review, we will clarify the characteristics of different assays for assessing MRD, focusing on its role as a risk-stratification biomarker to predict prognostic information and its role in optimal postremission therapy among older adult AML patients. These characteristics also provide guidance regarding the potential to apply personalized medicine in older adult AML patients.Keywords: detection method, risk-stratification marker, postremission decisions, personalized medicinehttps://www.dovepress.com/role-of-measurable-residual-disease-in-older-adult-acute-myeloid-leuke-peer-reviewed-fulltext-article-CIAdetection methodrisk-stratification markerpostremission decisionspersonalized medicine |
| spellingShingle | Li X Tong X Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia Clinical Interventions in Aging detection method risk-stratification marker postremission decisions personalized medicine |
| title | Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia |
| title_full | Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia |
| title_fullStr | Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia |
| title_full_unstemmed | Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia |
| title_short | Role of Measurable Residual Disease in Older Adult Acute Myeloid Leukemia |
| title_sort | role of measurable residual disease in older adult acute myeloid leukemia |
| topic | detection method risk-stratification marker postremission decisions personalized medicine |
| url | https://www.dovepress.com/role-of-measurable-residual-disease-in-older-adult-acute-myeloid-leuke-peer-reviewed-fulltext-article-CIA |
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