ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY
Studying of a role of gene polymorphisms during gestational process at pregnant women with obesity was the purpose. Selection 175 women with threat of interruption of pregnancy aged from 20 till 41 year (120 (68.6%) made women with an excess weight (the main group), 55 (31.4%) – with the normal body...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-06-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/95 |
| _version_ | 1797884190372397056 |
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| author | Z. M. Dubossarskaya Yu. M. Duka |
| author_facet | Z. M. Dubossarskaya Yu. M. Duka |
| author_sort | Z. M. Dubossarskaya |
| collection | DOAJ |
| description | Studying of a role of gene polymorphisms during gestational process at pregnant women with obesity was the purpose. Selection 175 women with threat of interruption of pregnancy aged from 20 till 41 year (120 (68.6%) made women with an excess weight (the main group), 55 (31.4%) – with the normal body weight (group of comparison)).Except the researches regulated by Orders of the Ministry of health care of Ukraine research of 12 genetic options of polymorphism of genes of a trombofiliya, and also polymorphism of a gene angiotenzinogena-1 (AGT Thr174Met), a gene angiotenzinogena-2 (AGT Met235Thr), mutations-1 of a sintaza of an oxide of nitrogen 3 (NOS3 C786T) is conducted by method of polimerazny chain reaction. Reliable correlation communication between existence of excess weight and arterial hypertension, a hyper coagulative syndrome, a mutation of factors of a fibrillation of F5 Leiden, F7, PAI gene-1, MTR gene is revealed: 2756 – B12-dependent methionine-sintazy. Direct correlation between polymorphism of genes of arterial hypertension and complications of the second half of pregnancy and childbirth is revealed. Thus it is proved that obesity and genetically caused trombofiliya are major factors of risk of development of complications of a gestation and the tromboembolicheskikh of complications. |
| first_indexed | 2024-04-10T04:02:26Z |
| format | Article |
| id | doaj.art-410f653ab121428a9e03f87e037f1b57 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:02:26Z |
| publishDate | 2016-06-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-410f653ab121428a9e03f87e037f1b572023-03-13T07:09:46ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-018461193ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITYZ. M. Dubossarskaya0Yu. M. Duka1Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine (Dnepropetrovsk, Ukraine)Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine (Dnepropetrovsk, Ukraine)Studying of a role of gene polymorphisms during gestational process at pregnant women with obesity was the purpose. Selection 175 women with threat of interruption of pregnancy aged from 20 till 41 year (120 (68.6%) made women with an excess weight (the main group), 55 (31.4%) – with the normal body weight (group of comparison)).Except the researches regulated by Orders of the Ministry of health care of Ukraine research of 12 genetic options of polymorphism of genes of a trombofiliya, and also polymorphism of a gene angiotenzinogena-1 (AGT Thr174Met), a gene angiotenzinogena-2 (AGT Met235Thr), mutations-1 of a sintaza of an oxide of nitrogen 3 (NOS3 C786T) is conducted by method of polimerazny chain reaction. Reliable correlation communication between existence of excess weight and arterial hypertension, a hyper coagulative syndrome, a mutation of factors of a fibrillation of F5 Leiden, F7, PAI gene-1, MTR gene is revealed: 2756 – B12-dependent methionine-sintazy. Direct correlation between polymorphism of genes of arterial hypertension and complications of the second half of pregnancy and childbirth is revealed. Thus it is proved that obesity and genetically caused trombofiliya are major factors of risk of development of complications of a gestation and the tromboembolicheskikh of complications.https://www.gynecology.su/jour/article/view/95obesitypregnancy interruptiontrombofiliyagene polymorphisms |
| spellingShingle | Z. M. Dubossarskaya Yu. M. Duka ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY Акушерство, гинекология и репродукция obesity pregnancy interruption trombofiliya gene polymorphisms |
| title | ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY |
| title_full | ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY |
| title_fullStr | ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY |
| title_full_unstemmed | ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY |
| title_short | ROLE OF GENE POLYMORPHISMS IN GENESIS OF GESTATIONAL COMPLICATIONS AT PREGNANT WOMEN WITH OBESITY |
| title_sort | role of gene polymorphisms in genesis of gestational complications at pregnant women with obesity |
| topic | obesity pregnancy interruption trombofiliya gene polymorphisms |
| url | https://www.gynecology.su/jour/article/view/95 |
| work_keys_str_mv | AT zmdubossarskaya roleofgenepolymorphismsingenesisofgestationalcomplicationsatpregnantwomenwithobesity AT yumduka roleofgenepolymorphismsingenesisofgestationalcomplicationsatpregnantwomenwithobesity |