Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children
ObjectivesNeuroblastoma (NBL) predominantly affects children under 5 years of age. Through multimodal therapy, including chemotherapy, radiotherapy, surgery, and peripheral blood stem cell transplantation, the survival rate in patients with NBL have improved while treatment-related complications hav...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2015-12-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-8-329.pdf |
| _version_ | 1819263229731274752 |
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| author | Nam-Gyu Ryu Il Joon Moon Young Soo Chang Byoung Kil Kim Won-Ho Chung Yang-Sun Cho Sung Hwa Hong |
| author_facet | Nam-Gyu Ryu Il Joon Moon Young Soo Chang Byoung Kil Kim Won-Ho Chung Yang-Sun Cho Sung Hwa Hong |
| author_sort | Nam-Gyu Ryu |
| collection | DOAJ |
| description | ObjectivesNeuroblastoma (NBL) predominantly affects children under 5 years of age. Through multimodal therapy, including chemotherapy, radiotherapy, surgery, and peripheral blood stem cell transplantation, the survival rate in patients with NBL have improved while treatment-related complications have also increased. Treatment-related ototoxicity, mainly from cisplatin, can result in profound hearing loss requiring cochlear implantation (CI). We analyzed the effectiveness and hearing preservation of CI recipients who had treated with multimodal therapy due to NBL.MethodsPatients who received multimodal therapy for NBL and subsequent CIs were enrolled. A detailed review of the perioperative hearing test, speech evaluation, and posttreatment complications was conducted. Speech performance was analyzed using the category of auditory performance (CAP) score and the postoperative hearing preservation of low frequencies was also compared. Patients who were candidates for electro-acoustic stimulation (EAS) used an EAS electrode for low frequency hearing preservation.ResultsThree patients were identified and all patients showed improvement of speech performance after CI. The average of CAP score improved from 4.3 preoperatively to 5.8 at 1 year postoperatively. Two patients who were fitted with the Flex electrode showed complete hearing preservation and the preserved hearing was maintained over 1 year. The one remaining patient was given the standard CI-512 electrode and showed partial hearing preservation.ConclusionPatients with profound hearing loss resulting from NBL multimodal therapy can be good candidates for CI, especially for EAS. A soft surgical technique as well as a specifically designed electrode should be applied to this specific population during the CI operation in order to preserve residual hearing and achieve better outcomes. |
| first_indexed | 2024-12-23T20:10:16Z |
| format | Article |
| id | doaj.art-411286b9a2d848b7b26fd43e3df097e4 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-23T20:10:16Z |
| publishDate | 2015-12-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-411286b9a2d848b7b26fd43e3df097e42022-12-21T17:32:49ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202015-12-018432933410.3342/ceo.2015.8.4.329389Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in ChildrenNam-Gyu Ryu0Il Joon Moon1Young Soo Chang2Byoung Kil Kim3Won-Ho Chung4Yang-Sun Cho5Sung Hwa Hong6Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ObjectivesNeuroblastoma (NBL) predominantly affects children under 5 years of age. Through multimodal therapy, including chemotherapy, radiotherapy, surgery, and peripheral blood stem cell transplantation, the survival rate in patients with NBL have improved while treatment-related complications have also increased. Treatment-related ototoxicity, mainly from cisplatin, can result in profound hearing loss requiring cochlear implantation (CI). We analyzed the effectiveness and hearing preservation of CI recipients who had treated with multimodal therapy due to NBL.MethodsPatients who received multimodal therapy for NBL and subsequent CIs were enrolled. A detailed review of the perioperative hearing test, speech evaluation, and posttreatment complications was conducted. Speech performance was analyzed using the category of auditory performance (CAP) score and the postoperative hearing preservation of low frequencies was also compared. Patients who were candidates for electro-acoustic stimulation (EAS) used an EAS electrode for low frequency hearing preservation.ResultsThree patients were identified and all patients showed improvement of speech performance after CI. The average of CAP score improved from 4.3 preoperatively to 5.8 at 1 year postoperatively. Two patients who were fitted with the Flex electrode showed complete hearing preservation and the preserved hearing was maintained over 1 year. The one remaining patient was given the standard CI-512 electrode and showed partial hearing preservation.ConclusionPatients with profound hearing loss resulting from NBL multimodal therapy can be good candidates for CI, especially for EAS. A soft surgical technique as well as a specifically designed electrode should be applied to this specific population during the CI operation in order to preserve residual hearing and achieve better outcomes.http://www.e-ceo.org/upload/pdf/ceo-8-329.pdfNeuroblastomaChemotherapyCochlear ImplantationHearing Loss |
| spellingShingle | Nam-Gyu Ryu Il Joon Moon Young Soo Chang Byoung Kil Kim Won-Ho Chung Yang-Sun Cho Sung Hwa Hong Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children Clinical and Experimental Otorhinolaryngology Neuroblastoma Chemotherapy Cochlear Implantation Hearing Loss |
| title | Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children |
| title_full | Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children |
| title_fullStr | Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children |
| title_full_unstemmed | Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children |
| title_short | Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children |
| title_sort | cochlear implantation for profound hearing loss after multimodal treatment for neuroblastoma in children |
| topic | Neuroblastoma Chemotherapy Cochlear Implantation Hearing Loss |
| url | http://www.e-ceo.org/upload/pdf/ceo-8-329.pdf |
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