Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/11/7/1172 |
| _version_ | 1797587291314585600 |
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| author | Brankica Filipić Ivana Pantelić Ines Nikolić Dragomira Majhen Zorica Stojić-Vukanić Snežana Savić Danina Krajišnik |
| author_facet | Brankica Filipić Ivana Pantelić Ines Nikolić Dragomira Majhen Zorica Stojić-Vukanić Snežana Savić Danina Krajišnik |
| author_sort | Brankica Filipić |
| collection | DOAJ |
| description | Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases. |
| first_indexed | 2024-03-11T00:35:04Z |
| format | Article |
| id | doaj.art-4113ceb0085b4d1a9c0f786f76c60918 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T00:35:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-4113ceb0085b4d1a9c0f786f76c609182023-11-18T21:40:41ZengMDPI AGVaccines2076-393X2023-06-01117117210.3390/vaccines11071172Nanoparticle-Based Adjuvants and Delivery Systems for Modern VaccinesBrankica Filipić0Ivana Pantelić1Ines Nikolić2Dragomira Majhen3Zorica Stojić-Vukanić4Snežana Savić5Danina Krajišnik6Department of Microbiology and Immunology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaDivision of Molecular Biology, Ruđer Bošković Institute, 10000 Zagreb, CroatiaDepartment of Microbiology and Immunology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaDepartment of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, 11000 Belgrade, SerbiaEver since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines and develop new vaccination strategies and vaccine platforms that induce a broader immune response compared to traditional vaccines. Modern vaccines tend to rely on certain nanotechnology platforms but are still expected to be readily available and easy for large-scale manufacturing and to induce a durable immune response. In this review, we present an overview of the most promising nanoadjuvants and nanoparticulate delivery systems and discuss their benefits from tehchnological and immunological standpoints as well as their objective drawbacks and possible side effects. The presented nano alums, silica and clay nanoparticles, nanoemulsions, adenoviral-vectored systems, adeno-associated viral vectors, vesicular stomatitis viral vectors, lentiviral vectors, virus-like particles (including bacteriophage-based ones) and virosomes indicate that vaccine developers can now choose different adjuvants and/or delivery systems as per the requirement, specific to combatting different infectious diseases.https://www.mdpi.com/2076-393X/11/7/1172nanoadjuvantsnanoemulsionsviral-vectored systemvirus-like particles |
| spellingShingle | Brankica Filipić Ivana Pantelić Ines Nikolić Dragomira Majhen Zorica Stojić-Vukanić Snežana Savić Danina Krajišnik Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines Vaccines nanoadjuvants nanoemulsions viral-vectored system virus-like particles |
| title | Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines |
| title_full | Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines |
| title_fullStr | Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines |
| title_full_unstemmed | Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines |
| title_short | Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines |
| title_sort | nanoparticle based adjuvants and delivery systems for modern vaccines |
| topic | nanoadjuvants nanoemulsions viral-vectored system virus-like particles |
| url | https://www.mdpi.com/2076-393X/11/7/1172 |
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