Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
Abstract Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs ar...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-06030-x |
| _version_ | 1797247056582017024 |
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| author | Yuichi Matsui Fumitaka Muramatsu Hajime Nakamura Yoshimi Noda Kinnosuke Matsumoto Haruhiko Kishima Nobuyuki Takakura |
| author_facet | Yuichi Matsui Fumitaka Muramatsu Hajime Nakamura Yoshimi Noda Kinnosuke Matsumoto Haruhiko Kishima Nobuyuki Takakura |
| author_sort | Yuichi Matsui |
| collection | DOAJ |
| description | Abstract Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors. The in vitro coculture of brain cells with ECs from several diverse organs suggested the function of brain-derived endothelium is affected within a brain environment due to netrin-1 and Unc 5B systems. We found brain CD157-positive ECs were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation. We propose novel methods to improve the symptoms of chronic cerebral hypoperfusion using CD157-positive ECs. |
| first_indexed | 2024-04-24T19:52:38Z |
| format | Article |
| id | doaj.art-41143db9623d4f73b40ca650899d8733 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-24T19:52:38Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-41143db9623d4f73b40ca650899d87332024-03-24T12:29:19ZengNature PortfolioCommunications Biology2399-36422024-03-017111410.1038/s42003-024-06030-xBrain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse modelYuichi Matsui0Fumitaka Muramatsu1Hajime Nakamura2Yoshimi Noda3Kinnosuke Matsumoto4Haruhiko Kishima5Nobuyuki Takakura6Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Neurosurgery, Osaka University Graduate School of MedicineDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Neurosurgery, Osaka University Graduate School of MedicineDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityAbstract Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors. The in vitro coculture of brain cells with ECs from several diverse organs suggested the function of brain-derived endothelium is affected within a brain environment due to netrin-1 and Unc 5B systems. We found brain CD157-positive ECs were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation. We propose novel methods to improve the symptoms of chronic cerebral hypoperfusion using CD157-positive ECs.https://doi.org/10.1038/s42003-024-06030-x |
| spellingShingle | Yuichi Matsui Fumitaka Muramatsu Hajime Nakamura Yoshimi Noda Kinnosuke Matsumoto Haruhiko Kishima Nobuyuki Takakura Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model Communications Biology |
| title | Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| title_full | Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| title_fullStr | Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| title_full_unstemmed | Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| title_short | Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| title_sort | brain derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model |
| url | https://doi.org/10.1038/s42003-024-06030-x |
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