The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis
Background/Objective: The significance of extended lymphadenectomy for colorectal cancer with extraregional lymph node metastasis, such as para-aortic lymph node metastasis, has not been established. The purpose of this study was to evaluate the significance of extended lymphadenectomy for colorecta...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-07-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958415001244 |
| _version_ | 1818650110887723008 |
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| author | Atsushi Ogura Takashi Akiyoshi Yukiko Takatsu Jun Nagata Toshiya Nagasaki Tsuyoshi Konishi Yoshiya Fujimoto Satoshi Nagayama Yosuke Fukunaga Masashi Ueno |
| author_facet | Atsushi Ogura Takashi Akiyoshi Yukiko Takatsu Jun Nagata Toshiya Nagasaki Tsuyoshi Konishi Yoshiya Fujimoto Satoshi Nagayama Yosuke Fukunaga Masashi Ueno |
| author_sort | Atsushi Ogura |
| collection | DOAJ |
| description | Background/Objective: The significance of extended lymphadenectomy for colorectal cancer with extraregional lymph node metastasis, such as para-aortic lymph node metastasis, has not been established. The purpose of this study was to evaluate the significance of extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis.
Methods: Between July 2004 and December 2013, 16 patients with synchronous extraregional lymph node metastasis without other organ metastases underwent curative resection and extended lymphadenectomy (R0 group). The clinical characteristics and survival outcomes of the R0 group were compared with those of 12 patients with extraregional lymph node metastasis who underwent palliative surgery (control group).
Results: In the R0 group, the 5-year cancer-specific survival (CSS) rate was 70.3% and the 5-year relapse-free survival (RFS) rate was 60.5%. The 5-year CSS differed significantly between the R0 and control groups (70.3% vs. 12.5%; p = 0.0003). Univariate analyses revealed that the total numbers of metastatic lymph nodes and metastatic regional lymph nodes present were significantly associated with RFS (p = 0.019 for both).
Conclusion: Findings from our study suggest that extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis might be effective in carefully selected patients. |
| first_indexed | 2024-12-17T01:45:01Z |
| format | Article |
| id | doaj.art-41172ad63c8a4620a8071605f981f3e1 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-17T01:45:01Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-41172ad63c8a4620a8071605f981f3e12022-12-21T22:08:13ZengElsevierAsian Journal of Surgery1015-95842017-07-0140425426110.1016/j.asjsur.2015.10.003The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasisAtsushi OguraTakashi AkiyoshiYukiko TakatsuJun NagataToshiya NagasakiTsuyoshi KonishiYoshiya FujimotoSatoshi NagayamaYosuke FukunagaMasashi UenoBackground/Objective: The significance of extended lymphadenectomy for colorectal cancer with extraregional lymph node metastasis, such as para-aortic lymph node metastasis, has not been established. The purpose of this study was to evaluate the significance of extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis. Methods: Between July 2004 and December 2013, 16 patients with synchronous extraregional lymph node metastasis without other organ metastases underwent curative resection and extended lymphadenectomy (R0 group). The clinical characteristics and survival outcomes of the R0 group were compared with those of 12 patients with extraregional lymph node metastasis who underwent palliative surgery (control group). Results: In the R0 group, the 5-year cancer-specific survival (CSS) rate was 70.3% and the 5-year relapse-free survival (RFS) rate was 60.5%. The 5-year CSS differed significantly between the R0 and control groups (70.3% vs. 12.5%; p = 0.0003). Univariate analyses revealed that the total numbers of metastatic lymph nodes and metastatic regional lymph nodes present were significantly associated with RFS (p = 0.019 for both). Conclusion: Findings from our study suggest that extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis might be effective in carefully selected patients.http://www.sciencedirect.com/science/article/pii/S1015958415001244colorectal cancerextended lymphadenectomyextraregional lymph node metastasisstage IV |
| spellingShingle | Atsushi Ogura Takashi Akiyoshi Yukiko Takatsu Jun Nagata Toshiya Nagasaki Tsuyoshi Konishi Yoshiya Fujimoto Satoshi Nagayama Yosuke Fukunaga Masashi Ueno The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis Asian Journal of Surgery colorectal cancer extended lymphadenectomy extraregional lymph node metastasis stage IV |
| title | The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| title_full | The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| title_fullStr | The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| title_full_unstemmed | The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| title_short | The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| title_sort | significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis |
| topic | colorectal cancer extended lymphadenectomy extraregional lymph node metastasis stage IV |
| url | http://www.sciencedirect.com/science/article/pii/S1015958415001244 |
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