The application of zebrafish model in the study of cleft lip and palate development: A systematic review
Objective: Craniofacial growth and development are more than a scientific curiosity; it is of tremendous interest to clinicians. Insights into the genetic etiology of cleft lip and palate development are essential for improving diagnosis and treatment planning. The purpose of this systematic review...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024043536 |
| _version_ | 1797224120520278016 |
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| author | Nora Alhazmi Khalid A. Alamoud Farraj Albalawi Bassam Alalola Fathima F. Farook |
| author_facet | Nora Alhazmi Khalid A. Alamoud Farraj Albalawi Bassam Alalola Fathima F. Farook |
| author_sort | Nora Alhazmi |
| collection | DOAJ |
| description | Objective: Craniofacial growth and development are more than a scientific curiosity; it is of tremendous interest to clinicians. Insights into the genetic etiology of cleft lip and palate development are essential for improving diagnosis and treatment planning. The purpose of this systematic review was to utilize a zebrafish model to highlight the role of the IRF6 gene in cleft lip and palate development in humans. Data: This review adhered to the guidelines outlined in the PRISMA statement. Nine studies were included in the analysis. Sources: This study used major scientific databases such as MEDLINE, EMBASE, Web of Science, and the Zebrafish Information Network and yielded 1275 articles. Two reviewers performed the screening using COVIDENCE™ independently, and a third reviewer resolved any conflicts. Study selection: After applying the inclusion and exclusion criteria and screening, nine studies were included in the analysis. The Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE's) risk-of-bias tool was used to assess the quality of the included studies. Results: The main outcome supports the role of the IRF6 gene in zebrafish periderm development and embryogenesis, and IRF6 variations result in cleft lip and palate development. The overall SYRCLE risk of bias was low-medium. Conclusion: In conclusion, this review indicated the critical role of the IRF6 gene and its downstream genes (GRHL3, KLF17, and ESRP1/2) in the development of cleft lip and palate in zebrafish models. Genetic mutation zebrafish models provide a high level of insights into zebrafish craniofacial development. Clinical relevance: this review provides a productive avenue for understanding the powerful and conserved zebrafish model for investigating the pathogenesis of human cleft lip and palate. |
| first_indexed | 2024-04-24T13:48:04Z |
| format | Article |
| id | doaj.art-4117b5acd5a54c3bb4edfc74143d93ca |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:48:04Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4117b5acd5a54c3bb4edfc74143d93ca2024-04-04T05:07:10ZengElsevierHeliyon2405-84402024-03-01106e28322The application of zebrafish model in the study of cleft lip and palate development: A systematic reviewNora Alhazmi0Khalid A. Alamoud1Farraj Albalawi2Bassam Alalola3Fathima F. Farook4Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia; Ministry of the National Guard Health Affairs, Riyadh, 11426, Saudi Arabia; Corresponding author. Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia.Preventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia; Ministry of the National Guard Health Affairs, Riyadh, 11426, Saudi ArabiaPreventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia; Ministry of the National Guard Health Affairs, Riyadh, 11426, Saudi ArabiaPreventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia; Ministry of the National Guard Health Affairs, Riyadh, 11426, Saudi ArabiaPreventive Dental Science Department, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, 14611, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, 11481, Saudi Arabia; Ministry of the National Guard Health Affairs, Riyadh, 11426, Saudi ArabiaObjective: Craniofacial growth and development are more than a scientific curiosity; it is of tremendous interest to clinicians. Insights into the genetic etiology of cleft lip and palate development are essential for improving diagnosis and treatment planning. The purpose of this systematic review was to utilize a zebrafish model to highlight the role of the IRF6 gene in cleft lip and palate development in humans. Data: This review adhered to the guidelines outlined in the PRISMA statement. Nine studies were included in the analysis. Sources: This study used major scientific databases such as MEDLINE, EMBASE, Web of Science, and the Zebrafish Information Network and yielded 1275 articles. Two reviewers performed the screening using COVIDENCE™ independently, and a third reviewer resolved any conflicts. Study selection: After applying the inclusion and exclusion criteria and screening, nine studies were included in the analysis. The Systematic Review Center for Laboratory Animal Experimentation's (SYRCLE's) risk-of-bias tool was used to assess the quality of the included studies. Results: The main outcome supports the role of the IRF6 gene in zebrafish periderm development and embryogenesis, and IRF6 variations result in cleft lip and palate development. The overall SYRCLE risk of bias was low-medium. Conclusion: In conclusion, this review indicated the critical role of the IRF6 gene and its downstream genes (GRHL3, KLF17, and ESRP1/2) in the development of cleft lip and palate in zebrafish models. Genetic mutation zebrafish models provide a high level of insights into zebrafish craniofacial development. Clinical relevance: this review provides a productive avenue for understanding the powerful and conserved zebrafish model for investigating the pathogenesis of human cleft lip and palate.http://www.sciencedirect.com/science/article/pii/S2405844024043536ZebrafishDanio rerioEthmoid plateCleft lipCleft palateCleft |
| spellingShingle | Nora Alhazmi Khalid A. Alamoud Farraj Albalawi Bassam Alalola Fathima F. Farook The application of zebrafish model in the study of cleft lip and palate development: A systematic review Heliyon Zebrafish Danio rerio Ethmoid plate Cleft lip Cleft palate Cleft |
| title | The application of zebrafish model in the study of cleft lip and palate development: A systematic review |
| title_full | The application of zebrafish model in the study of cleft lip and palate development: A systematic review |
| title_fullStr | The application of zebrafish model in the study of cleft lip and palate development: A systematic review |
| title_full_unstemmed | The application of zebrafish model in the study of cleft lip and palate development: A systematic review |
| title_short | The application of zebrafish model in the study of cleft lip and palate development: A systematic review |
| title_sort | application of zebrafish model in the study of cleft lip and palate development a systematic review |
| topic | Zebrafish Danio rerio Ethmoid plate Cleft lip Cleft palate Cleft |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024043536 |
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