Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy
Three-dimensional image formation in microscopy is greatly enhanced by the use of computed imaging techniques. In particular, Interferometric Synthetic Aperture Microscopy (ISAM) allows the removal of out-of-focus blur in broadband, coherent microscopy. Earlier methods, such as optical coherence tom...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2008-06-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/8/6/3903/ |
| _version_ | 1818035029551349760 |
|---|---|
| author | Stephen A. Boppart P. Scott Carney Tyler S. Ralston Daniel L. Marks Brynmor J. Davis |
| author_facet | Stephen A. Boppart P. Scott Carney Tyler S. Ralston Daniel L. Marks Brynmor J. Davis |
| author_sort | Stephen A. Boppart |
| collection | DOAJ |
| description | Three-dimensional image formation in microscopy is greatly enhanced by the use of computed imaging techniques. In particular, Interferometric Synthetic Aperture Microscopy (ISAM) allows the removal of out-of-focus blur in broadband, coherent microscopy. Earlier methods, such as optical coherence tomography (OCT), utilize interferometric ranging, but do not apply computed imaging methods and therefore must scan the focal depth to acquire extended volumetric images. ISAM removes the need to scan the focus by allowing volumetric image reconstruction from data collected at a single focal depth. ISAM signal processing techniques are similar to the Fourier migration methods of seismology and the Fourier reconstruction methods of Synthetic Aperture Radar (SAR). In this article ISAM is described and the close ties between ISAM and SAR are explored. ISAM and a simple strip-map SAR system are placed in a common mathematical framework and compared to OCT and radar respectively. This article is intended to serve as a review of ISAM, and will be especially useful to readers with a background in SAR. |
| first_indexed | 2024-12-10T06:48:33Z |
| format | Article |
| id | doaj.art-411dc1045ea24da59d64ca4a9f8a624c |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-12-10T06:48:33Z |
| publishDate | 2008-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-411dc1045ea24da59d64ca4a9f8a624c2022-12-22T01:58:36ZengMDPI AGSensors1424-82202008-06-018639033931Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent MicroscopyStephen A. BoppartP. Scott CarneyTyler S. RalstonDaniel L. MarksBrynmor J. DavisThree-dimensional image formation in microscopy is greatly enhanced by the use of computed imaging techniques. In particular, Interferometric Synthetic Aperture Microscopy (ISAM) allows the removal of out-of-focus blur in broadband, coherent microscopy. Earlier methods, such as optical coherence tomography (OCT), utilize interferometric ranging, but do not apply computed imaging methods and therefore must scan the focal depth to acquire extended volumetric images. ISAM removes the need to scan the focus by allowing volumetric image reconstruction from data collected at a single focal depth. ISAM signal processing techniques are similar to the Fourier migration methods of seismology and the Fourier reconstruction methods of Synthetic Aperture Radar (SAR). In this article ISAM is described and the close ties between ISAM and SAR are explored. ISAM and a simple strip-map SAR system are placed in a common mathematical framework and compared to OCT and radar respectively. This article is intended to serve as a review of ISAM, and will be especially useful to readers with a background in SAR.http://www.mdpi.com/1424-8220/8/6/3903/MicroscopyInterferometricSynthetic ApertureRadarOptical Coherence Tomography. |
| spellingShingle | Stephen A. Boppart P. Scott Carney Tyler S. Ralston Daniel L. Marks Brynmor J. Davis Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy Sensors Microscopy Interferometric Synthetic Aperture Radar Optical Coherence Tomography. |
| title | Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy |
| title_full | Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy |
| title_fullStr | Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy |
| title_full_unstemmed | Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy |
| title_short | Interferometric Synthetic Aperture Microscopy: Computed Imaging for Scanned Coherent Microscopy |
| title_sort | interferometric synthetic aperture microscopy computed imaging for scanned coherent microscopy |
| topic | Microscopy Interferometric Synthetic Aperture Radar Optical Coherence Tomography. |
| url | http://www.mdpi.com/1424-8220/8/6/3903/ |
| work_keys_str_mv | AT stephenaboppart interferometricsyntheticaperturemicroscopycomputedimagingforscannedcoherentmicroscopy AT pscottcarney interferometricsyntheticaperturemicroscopycomputedimagingforscannedcoherentmicroscopy AT tylersralston interferometricsyntheticaperturemicroscopycomputedimagingforscannedcoherentmicroscopy AT daniellmarks interferometricsyntheticaperturemicroscopycomputedimagingforscannedcoherentmicroscopy AT brynmorjdavis interferometricsyntheticaperturemicroscopycomputedimagingforscannedcoherentmicroscopy |