Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed c...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500011&lng=en&tlng=en |
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| author | Edmundo P.A. Lopes Lucila M. Valente A. Eduardo B. Silva Gianna Mastroianni Kirsztajn Cibele N. Cruz Maria Lucia G Ferraz |
| author_facet | Edmundo P.A. Lopes Lucila M. Valente A. Eduardo B. Silva Gianna Mastroianni Kirsztajn Cibele N. Cruz Maria Lucia G Ferraz |
| author_sort | Edmundo P.A. Lopes |
| collection | DOAJ |
| description | We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV. |
| first_indexed | 2024-12-13T07:56:25Z |
| format | Article |
| id | doaj.art-411e96ae7c1e437495409e70343ce895 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-13T07:56:25Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-411e96ae7c1e437495409e70343ce8952022-12-21T23:54:31ZengElsevierBrazilian Journal of Infectious Diseases1678-43917535335710.1590/S1413-86702003000500011S1413-86702003000500011Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virusEdmundo P.A. Lopes0Lucila M. Valente1A. Eduardo B. Silva2Gianna Mastroianni Kirsztajn3Cibele N. Cruz4Maria Lucia G Ferraz5Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloWe describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500011&lng=en&tlng=enGlomerulonephritishepatitis Cinterferonribavirin |
| spellingShingle | Edmundo P.A. Lopes Lucila M. Valente A. Eduardo B. Silva Gianna Mastroianni Kirsztajn Cibele N. Cruz Maria Lucia G Ferraz Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus Brazilian Journal of Infectious Diseases Glomerulonephritis hepatitis C interferon ribavirin |
| title | Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
| title_full | Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
| title_fullStr | Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
| title_full_unstemmed | Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
| title_short | Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
| title_sort | therapy with interferon alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis c virus |
| topic | Glomerulonephritis hepatitis C interferon ribavirin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500011&lng=en&tlng=en |
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