Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan
This retrospective cohort study enrolled 385 patients diagnosed with cutaneous melanoma from 1980 to 2021 in National Taiwan University Hospital (NTUH). The aim of this study was to investigate the relationship between thickness of primary melanoma lesions and disease outcome of melanoma patients, i...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664621005349 |
| _version_ | 1797995859070156800 |
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| author | Tung-Lin Lee Ming-Hsien Lin Yi-Hua Liao Jau-Yu Liau Yi-Shuan Sheen |
| author_facet | Tung-Lin Lee Ming-Hsien Lin Yi-Hua Liao Jau-Yu Liau Yi-Shuan Sheen |
| author_sort | Tung-Lin Lee |
| collection | DOAJ |
| description | This retrospective cohort study enrolled 385 patients diagnosed with cutaneous melanoma from 1980 to 2021 in National Taiwan University Hospital (NTUH). The aim of this study was to investigate the relationship between thickness of primary melanoma lesions and disease outcome of melanoma patients, in particular, those diagnosed with acral lentiginous melanoma (ALM). The association between important clinicopathological characteristics other than tumor thickness and disease outcome was also analyzed. Survival analyses with the Kaplan-Meier method were utilized to investigate the prognoses of patients with different lesion thickness. The male-to-female ratio was 1.12:1. The median age at diagnosis was 63 years old (mean: 62.2 years). There were 283 cases (73.5%) of acral lentiginous melanoma (ALM) with a male-to-female ratio of 1.04:1. Between patients with primary ALM lesions 4.1 millimeters (mm) to 8.0 mm thick and those with lesions over 8.0 mm thick, significant differences in prognostic outcomes including incidence of second recurrences within 1 year (raw p = 0.003, Bonferroni corrected p = 0.009) and distant metastases within 1 year (raw p = 0.003, Bonferroni corrected p = 0.008), were observed. Significantly worse 1-year (raw p = 0.01, Bonferroni corrected p=0.03) and 2-year survival (raw p = 0.006, Bonferroni corrected p = 0.02) were found in ALM patients with lesions of over 8 mm thick than those with lesions 4.1 mm to 8.0 mm at diagnosis. Vigilant short-term follow-up is warranted in ALM patients with lesions of over 8.0 mm thick at diagnosis due to higher risks of adverse outcome. |
| first_indexed | 2024-04-11T10:08:19Z |
| format | Article |
| id | doaj.art-411f470a669c464484fda3fd6ac4ca2a |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-11T10:08:19Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-411f470a669c464484fda3fd6ac4ca2a2022-12-22T04:30:10ZengElsevierJournal of the Formosan Medical Association0929-66462022-11-011211123382344Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in TaiwanTung-Lin Lee0Ming-Hsien Lin1Yi-Hua Liao2Jau-Yu Liau3Yi-Shuan Sheen4Department of Medical Education, National Taiwan University Hospital, Taipei, TaiwanDepartment of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, TaiwanDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Dermatology, National Taiwan University Hospital, 7 Chung-Shan S. Rd., Taipei, 100, Taiwan. Fax: +886 2 23934177.This retrospective cohort study enrolled 385 patients diagnosed with cutaneous melanoma from 1980 to 2021 in National Taiwan University Hospital (NTUH). The aim of this study was to investigate the relationship between thickness of primary melanoma lesions and disease outcome of melanoma patients, in particular, those diagnosed with acral lentiginous melanoma (ALM). The association between important clinicopathological characteristics other than tumor thickness and disease outcome was also analyzed. Survival analyses with the Kaplan-Meier method were utilized to investigate the prognoses of patients with different lesion thickness. The male-to-female ratio was 1.12:1. The median age at diagnosis was 63 years old (mean: 62.2 years). There were 283 cases (73.5%) of acral lentiginous melanoma (ALM) with a male-to-female ratio of 1.04:1. Between patients with primary ALM lesions 4.1 millimeters (mm) to 8.0 mm thick and those with lesions over 8.0 mm thick, significant differences in prognostic outcomes including incidence of second recurrences within 1 year (raw p = 0.003, Bonferroni corrected p = 0.009) and distant metastases within 1 year (raw p = 0.003, Bonferroni corrected p = 0.008), were observed. Significantly worse 1-year (raw p = 0.01, Bonferroni corrected p=0.03) and 2-year survival (raw p = 0.006, Bonferroni corrected p = 0.02) were found in ALM patients with lesions of over 8 mm thick than those with lesions 4.1 mm to 8.0 mm at diagnosis. Vigilant short-term follow-up is warranted in ALM patients with lesions of over 8.0 mm thick at diagnosis due to higher risks of adverse outcome.http://www.sciencedirect.com/science/article/pii/S0929664621005349Acral melanomaDisease-free survivalMetastasisPrognosisRecurrence |
| spellingShingle | Tung-Lin Lee Ming-Hsien Lin Yi-Hua Liao Jau-Yu Liau Yi-Shuan Sheen Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan Journal of the Formosan Medical Association Acral melanoma Disease-free survival Metastasis Prognosis Recurrence |
| title | Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan |
| title_full | Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan |
| title_fullStr | Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan |
| title_full_unstemmed | Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan |
| title_short | Clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in Taiwan |
| title_sort | clinicopathological characteristics and prognosis in significantly thick acral lentiginous melanoma in taiwan |
| topic | Acral melanoma Disease-free survival Metastasis Prognosis Recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S0929664621005349 |
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