Biological aspects of application of nanomaterials in tissue engineering
Millions of patients worldwide need surgery to repair or replace tissue that has been damaged through trauma or disease. To solve the problem of lost tissue, a major emphasis of tissue engineering (TE) is on tissue regeneration. Stem cells and highly porous biomaterials used as cell carrier...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of the Chemical Engineers of Serbia
2016-01-01
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| Series: | Chemical Industry and Chemical Engineering Quarterly |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1451-9372/2016/1451-93721500028M.pdf |
| Summary: | Millions of patients worldwide need surgery to repair or replace tissue that
has been damaged through trauma or disease. To solve the problem of lost
tissue, a major emphasis of tissue engineering (TE) is on tissue
regeneration. Stem cells and highly porous biomaterials used as cell carriers
(scaffolds) have an essential role in the production of new tissue by TE.
Cellular component is important for the generation and establishment of the
extracellular matrix, while a scaffold is necessary to determine the shape of
the newly formed tissue and facilitate migration of cells into the desired
location, as well as their growth and differentiation. This review describes
the types, characteristics and classification of stem cells. Furthermore, it
includes functional features of cell carriers - biocompatibility,
biodegradability and mechanical properties of biomaterials used in developing
state-of-the-art scaffolds for TE applications, as well as suitability for
different tissues. Moreover, it explains the importance of nanotechnology and
defines the challenges and the purpose of future research in this rapidly
advancing field. [Projekat Ministarstva nauke Republike Srbije, br. 41030 i
br. 172026] |
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| ISSN: | 1451-9372 2217-7434 |