Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma
Abstract Background Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon ion radiotherapy (C-ion RT) in locally advanced HCC (LAHCC). Methods The...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Radiation Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s13014-020-01634-z |
| _version_ | 1818120387720904704 |
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| author | Shintaro Shiba Kei Shibuya Masahiko Okamoto Shohei Okazaki Shuichiro Komatsu Yoshiki Kubota Takashi Nakano Tatsuya Ohno |
| author_facet | Shintaro Shiba Kei Shibuya Masahiko Okamoto Shohei Okazaki Shuichiro Komatsu Yoshiki Kubota Takashi Nakano Tatsuya Ohno |
| author_sort | Shintaro Shiba |
| collection | DOAJ |
| description | Abstract Background Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon ion radiotherapy (C-ion RT) in locally advanced HCC (LAHCC). Methods The data of 11 consecutive patients with LAHCC who received C-ion RT were analyzed. The C-ion RT doses of 52.8 Gy (relative biological effectiveness [RBE]) and 60.0 Gy (RBE) were delivered in 4 fractions for standard cases, and the 60.0 Gy dose was delivered in 12 fractions for close-to-gastrointestinal-tract cases. Survival and local control probabilities were calculated using the Kaplan-Meier method. Results The median follow-up duration after C-ion RT was 36.4 months. The median age at the time of registration for C-ion RT was 76 years. The median tumor size was 53 mm. The numbers of treatment-naive and recurrent HCC patients were 1 and 10, respectively. Direct invasion of the major branch of the portal vein, hepatic vein, or both portal and hepatic veins was observed in three, five, and three patients, respectively. The 3-year overall survival, local control, and progression-free survival rates were 64, 78, and 18%, respectively. No patient developed radiation-induced liver diseases or grade 3 or higher toxicities in the acute and late phases. Conclusions C-ion RT showed favorable clinical outcomes with a high rate of local control and minimal toxicities in LAHCC. Our findings suggest that C-ion RT is a promising multidisciplinary treatment option in LAHCC. |
| first_indexed | 2024-12-11T05:25:17Z |
| format | Article |
| id | doaj.art-4121782b0f834902b6f9ad3d10ec3e0d |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-11T05:25:17Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-4121782b0f834902b6f9ad3d10ec3e0d2022-12-22T01:19:36ZengBMCRadiation Oncology1748-717X2020-08-011511810.1186/s13014-020-01634-zClinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinomaShintaro Shiba0Kei Shibuya1Masahiko Okamoto2Shohei Okazaki3Shuichiro Komatsu4Yoshiki Kubota5Takashi Nakano6Tatsuya Ohno7Department of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineGunma University Heavy Ion Medical CenterDepartment of Radiation Oncology, Gunma University Graduate School of MedicineDepartment of Radiation Oncology, Gunma University Graduate School of MedicineAbstract Background Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon ion radiotherapy (C-ion RT) in locally advanced HCC (LAHCC). Methods The data of 11 consecutive patients with LAHCC who received C-ion RT were analyzed. The C-ion RT doses of 52.8 Gy (relative biological effectiveness [RBE]) and 60.0 Gy (RBE) were delivered in 4 fractions for standard cases, and the 60.0 Gy dose was delivered in 12 fractions for close-to-gastrointestinal-tract cases. Survival and local control probabilities were calculated using the Kaplan-Meier method. Results The median follow-up duration after C-ion RT was 36.4 months. The median age at the time of registration for C-ion RT was 76 years. The median tumor size was 53 mm. The numbers of treatment-naive and recurrent HCC patients were 1 and 10, respectively. Direct invasion of the major branch of the portal vein, hepatic vein, or both portal and hepatic veins was observed in three, five, and three patients, respectively. The 3-year overall survival, local control, and progression-free survival rates were 64, 78, and 18%, respectively. No patient developed radiation-induced liver diseases or grade 3 or higher toxicities in the acute and late phases. Conclusions C-ion RT showed favorable clinical outcomes with a high rate of local control and minimal toxicities in LAHCC. Our findings suggest that C-ion RT is a promising multidisciplinary treatment option in LAHCC.http://link.springer.com/article/10.1186/s13014-020-01634-zCarbon ion radiotherapyHepatocellular carcinomaHypofractionationVascular invasion |
| spellingShingle | Shintaro Shiba Kei Shibuya Masahiko Okamoto Shohei Okazaki Shuichiro Komatsu Yoshiki Kubota Takashi Nakano Tatsuya Ohno Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma Radiation Oncology Carbon ion radiotherapy Hepatocellular carcinoma Hypofractionation Vascular invasion |
| title | Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| title_full | Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| title_fullStr | Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| title_full_unstemmed | Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| title_short | Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| title_sort | clinical impact of hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma |
| topic | Carbon ion radiotherapy Hepatocellular carcinoma Hypofractionation Vascular invasion |
| url | http://link.springer.com/article/10.1186/s13014-020-01634-z |
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