Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs
Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of mammals. The purposes of this study were to exami...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Veterinary Medicine, Chiang Mai University
2021-05-01
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| Series: | Veterinary Integrative Sciences |
| Online Access: | https://he02.tci-thaijo.org/index.php/vis/article/view/251558 |
| _version_ | 1797837767201259520 |
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| author | Worrarak Norseeda Guisheng Liu Tawatchai Teltathum Korawan Sringarm Watcharapong Naraballobh Trisadee Khamlor Supamit Mekchay |
| author_facet | Worrarak Norseeda Guisheng Liu Tawatchai Teltathum Korawan Sringarm Watcharapong Naraballobh Trisadee Khamlor Supamit Mekchay |
| author_sort | Worrarak Norseeda |
| collection | DOAJ |
| description | Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of mammals. The purposes of this study were to examine polymorphisms in the porcine IL17RA gene and to assess its effects on litter size traits in Large White and Landrace pigs. Three non-synonymous single nucleotide polymorphisms (SNPs) in the porcine IL17RA gene were verified. The porcine IL17RA c.785C>T (p.Ala262Val) was found to be segregating in the Large White and Landrace pigs. No polymorphisms in the coding region of the porcine IL17RA gene at the two non-synonymous SNPs loci of c.997G>A (p.Val333Ile) and c.1962T>G (p.Asp654Glu) were found. The porcine IL17RA c.785C>T polymorphism was significantly associated with the total number born (TNB) and the number born alive (NBA) in Large White pigs (P<0.05). Moreover, the porcine IL17RA c.785C>T was significantly associated with the TNB, NBA, total birth weight (TBW), and total weaning weight of piglets at 21 days (TWW) in Landrace pigs (P<0.05). These results supported the importance of the porcine IL17RA gene in the litter size traits of pigs. Thus, the porcine IL17RA could be used as a potential candidate gene for improving litter size traits in pig breeding. |
| first_indexed | 2024-04-09T15:31:01Z |
| format | Article |
| id | doaj.art-4121dae7497d4af4aee107fae83e56db |
| institution | Directory Open Access Journal |
| issn | 2629-9968 |
| language | English |
| last_indexed | 2024-04-09T15:31:01Z |
| publishDate | 2021-05-01 |
| publisher | Faculty of Veterinary Medicine, Chiang Mai University |
| record_format | Article |
| series | Veterinary Integrative Sciences |
| spelling | doaj.art-4121dae7497d4af4aee107fae83e56db2023-04-28T08:22:51ZengFaculty of Veterinary Medicine, Chiang Mai UniversityVeterinary Integrative Sciences2629-99682021-05-0119339140510.12982/VIS.2021.033Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigsWorrarak NorseedaGuisheng LiuTawatchai TeltathumKorawan SringarmWatcharapong NaraballobhTrisadee KhamlorSupamit Mekchay Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of mammals. The purposes of this study were to examine polymorphisms in the porcine IL17RA gene and to assess its effects on litter size traits in Large White and Landrace pigs. Three non-synonymous single nucleotide polymorphisms (SNPs) in the porcine IL17RA gene were verified. The porcine IL17RA c.785C>T (p.Ala262Val) was found to be segregating in the Large White and Landrace pigs. No polymorphisms in the coding region of the porcine IL17RA gene at the two non-synonymous SNPs loci of c.997G>A (p.Val333Ile) and c.1962T>G (p.Asp654Glu) were found. The porcine IL17RA c.785C>T polymorphism was significantly associated with the total number born (TNB) and the number born alive (NBA) in Large White pigs (P<0.05). Moreover, the porcine IL17RA c.785C>T was significantly associated with the TNB, NBA, total birth weight (TBW), and total weaning weight of piglets at 21 days (TWW) in Landrace pigs (P<0.05). These results supported the importance of the porcine IL17RA gene in the litter size traits of pigs. Thus, the porcine IL17RA could be used as a potential candidate gene for improving litter size traits in pig breeding.https://he02.tci-thaijo.org/index.php/vis/article/view/251558 |
| spellingShingle | Worrarak Norseeda Guisheng Liu Tawatchai Teltathum Korawan Sringarm Watcharapong Naraballobh Trisadee Khamlor Supamit Mekchay Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs Veterinary Integrative Sciences |
| title | Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs |
| title_full | Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs |
| title_fullStr | Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs |
| title_full_unstemmed | Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs |
| title_short | Association of a non-synonymous SNP of IL17RA gene with litter size traits in Large White and Landrace pigs |
| title_sort | association of a non synonymous snp of il17ra gene with litter size traits in large white and landrace pigs |
| url | https://he02.tci-thaijo.org/index.php/vis/article/view/251558 |
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