Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase
The autoxidation-degradation processes of polyunsaturated fatty acids give rise to toxic products, and the relative toxicity at different stages of the process is of great interest. We report here that when methyl α-linolenate is exposed to sunlight and air, its antimicrobial activity against yeasts...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/1/35 |
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| author | Jorma Matikainen Markku Lehtinen Eila Pelttari Hannu Elo |
| author_facet | Jorma Matikainen Markku Lehtinen Eila Pelttari Hannu Elo |
| author_sort | Jorma Matikainen |
| collection | DOAJ |
| description | The autoxidation-degradation processes of polyunsaturated fatty acids give rise to toxic products, and the relative toxicity at different stages of the process is of great interest. We report here that when methyl α-linolenate is exposed to sunlight and air, its antimicrobial activity against yeasts and bacteria (as measured by agar diffusion) reaches its maximum during the early oxidative phase when addition of oxygen occurs and the mass increases drastically. Before exposure, the activity is minimal or zero, but it increases rapidly during the first days of the test, simultaneously with the increase of the mass of the material, and begins to decrease while the mass is still increasing and before the mass begins to decrease due to degradation and formation of volatile compounds. Thus, the products formed during the degradation phase of the process are far less toxic to the test organisms than the compounds formed at the early stages when addition of oxygen occurs with maximal rate. |
| first_indexed | 2024-04-12T01:01:00Z |
| format | Article |
| id | doaj.art-4123c35b9f394ff59f8265b141dd9ca0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T01:01:00Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4123c35b9f394ff59f8265b141dd9ca02022-12-22T03:54:27ZengMDPI AGMolecules1420-30492014-12-01201354210.3390/molecules20010035molecules20010035Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative PhaseJorma Matikainen0Markku Lehtinen1Eila Pelttari2Hannu Elo3Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55 (A. I. Virtasen aukio 1), FI-00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Biocenter 1, Viikinkaari 9), FI-00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Biocenter 1, Viikinkaari 9), FI-00014 Helsinki, FinlandDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Biocenter 1, Viikinkaari 9), FI-00014 Helsinki, FinlandThe autoxidation-degradation processes of polyunsaturated fatty acids give rise to toxic products, and the relative toxicity at different stages of the process is of great interest. We report here that when methyl α-linolenate is exposed to sunlight and air, its antimicrobial activity against yeasts and bacteria (as measured by agar diffusion) reaches its maximum during the early oxidative phase when addition of oxygen occurs and the mass increases drastically. Before exposure, the activity is minimal or zero, but it increases rapidly during the first days of the test, simultaneously with the increase of the mass of the material, and begins to decrease while the mass is still increasing and before the mass begins to decrease due to degradation and formation of volatile compounds. Thus, the products formed during the degradation phase of the process are far less toxic to the test organisms than the compounds formed at the early stages when addition of oxygen occurs with maximal rate.http://www.mdpi.com/1420-3049/20/1/35polyunsaturated fatty acidsfatty acid estersautoxidationweighing methodantibacterial activityantifungal activitytoxicityα-linolenic acid methyl ester |
| spellingShingle | Jorma Matikainen Markku Lehtinen Eila Pelttari Hannu Elo Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase Molecules polyunsaturated fatty acids fatty acid esters autoxidation weighing method antibacterial activity antifungal activity toxicity α-linolenic acid methyl ester |
| title | Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase |
| title_full | Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase |
| title_fullStr | Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase |
| title_full_unstemmed | Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase |
| title_short | Toxicity of Fatty Acid Autoxidation Products: Highest Anti-Microbial Toxicity in the Initial Oxidative Phase |
| title_sort | toxicity of fatty acid autoxidation products highest anti microbial toxicity in the initial oxidative phase |
| topic | polyunsaturated fatty acids fatty acid esters autoxidation weighing method antibacterial activity antifungal activity toxicity α-linolenic acid methyl ester |
| url | http://www.mdpi.com/1420-3049/20/1/35 |
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