Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis

Objective: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. Methodology: Using the visual analysis software, this study con...

Full description

Bibliographic Details
Main Authors: Jun Zhao, Yujie Feng, Guang-wei Liu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024038635
_version_ 1797224186463125504
author Jun Zhao
Yujie Feng
Guang-wei Liu
author_facet Jun Zhao
Yujie Feng
Guang-wei Liu
author_sort Jun Zhao
collection DOAJ
description Objective: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. Methodology: Using the visual analysis software, this study conducted quantitative statistics and visualization research on the relevant literature concerning immune-related adverse events caused by immune checkpoint inhibitors in the Web of Science Core Collection Database. By evaluating the publication trends, countries, institutions, keywords, research status, cited documents, and document co-citations, among several others, the discussion revolved around the hot spots and future development trends in this field and provided references for future research. Findings and conclusions: A total of 514 English articles were included, and the top three countries in the research field at the time of this study were the United States, Japan, and China. More specifically, the University of Texas MD Anderson Cancer Center, Dana-Farber Cancer Institute, and Massachusetts General Hospital have been the top three research institutes with more than 10 publications. The frequency of keyword use linked to immune-related adverse events caused by immune checkpoint inhibitors in literature research has been steadily growing over the years. Additionally, the research with respect to the disease focuses on melanoma, cell lung cancer, hepatocellular carcinoma, and breast cancer. In the context of drugs, cancer-related research has mainly focused on the combined use of nivolumab, pembrolizumab, ipilimumab, and immune checkpoint inhibitors. Meanwhile, research on adverse events has delved into the immune checkpoint inhibitors causing vitiligo, thyroid dysfunction, pancreatitis, cholangitis, and rheumatism. Related studies cover acute arthritis, myositis, acute kidney injury, as well as the combination therapy of immune checkpoint inhibitors and docetaxel, management of irAEs in cancer immunotherapy, and biomarkers of immune adverse reactions of immune checkpoint inhibitors. Finally, case report studies of immune adverse reactions caused by immune checkpoint inhibitors could serve as research hotspots in the future.
first_indexed 2024-04-24T13:49:07Z
format Article
id doaj.art-412458318bf74793a928684af011de87
institution Directory Open Access Journal
issn 2405-8440
language English
last_indexed 2024-04-24T13:49:07Z
publishDate 2024-03-01
publisher Elsevier
record_format Article
series Heliyon
spelling doaj.art-412458318bf74793a928684af011de872024-04-04T05:06:06ZengElsevierHeliyon2405-84402024-03-01106e27832Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysisJun Zhao0Yujie Feng1Guang-wei Liu2Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, shandong, 266003, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, shandong, 266003, China; Corresponding author.Objective: The primary objective of this paper is to investigate the research hotspots and future trends of immune-related adverse events induced by immune checkpoint inhibitors, offering valuable insights for researchers in this field. Methodology: Using the visual analysis software, this study conducted quantitative statistics and visualization research on the relevant literature concerning immune-related adverse events caused by immune checkpoint inhibitors in the Web of Science Core Collection Database. By evaluating the publication trends, countries, institutions, keywords, research status, cited documents, and document co-citations, among several others, the discussion revolved around the hot spots and future development trends in this field and provided references for future research. Findings and conclusions: A total of 514 English articles were included, and the top three countries in the research field at the time of this study were the United States, Japan, and China. More specifically, the University of Texas MD Anderson Cancer Center, Dana-Farber Cancer Institute, and Massachusetts General Hospital have been the top three research institutes with more than 10 publications. The frequency of keyword use linked to immune-related adverse events caused by immune checkpoint inhibitors in literature research has been steadily growing over the years. Additionally, the research with respect to the disease focuses on melanoma, cell lung cancer, hepatocellular carcinoma, and breast cancer. In the context of drugs, cancer-related research has mainly focused on the combined use of nivolumab, pembrolizumab, ipilimumab, and immune checkpoint inhibitors. Meanwhile, research on adverse events has delved into the immune checkpoint inhibitors causing vitiligo, thyroid dysfunction, pancreatitis, cholangitis, and rheumatism. Related studies cover acute arthritis, myositis, acute kidney injury, as well as the combination therapy of immune checkpoint inhibitors and docetaxel, management of irAEs in cancer immunotherapy, and biomarkers of immune adverse reactions of immune checkpoint inhibitors. Finally, case report studies of immune adverse reactions caused by immune checkpoint inhibitors could serve as research hotspots in the future.http://www.sciencedirect.com/science/article/pii/S2405844024038635Immune checkpoint inhibitorsImmune-related adverse eventBibliometricsVisualized analysis
spellingShingle Jun Zhao
Yujie Feng
Guang-wei Liu
Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
Heliyon
Immune checkpoint inhibitors
Immune-related adverse event
Bibliometrics
Visualized analysis
title Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
title_full Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
title_fullStr Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
title_full_unstemmed Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
title_short Knowledge domains and emerging trends in immune-related adverse events from immune checkpoint inhibitors: A bibliometrics and visualized analysis
title_sort knowledge domains and emerging trends in immune related adverse events from immune checkpoint inhibitors a bibliometrics and visualized analysis
topic Immune checkpoint inhibitors
Immune-related adverse event
Bibliometrics
Visualized analysis
url http://www.sciencedirect.com/science/article/pii/S2405844024038635
work_keys_str_mv AT junzhao knowledgedomainsandemergingtrendsinimmunerelatedadverseeventsfromimmunecheckpointinhibitorsabibliometricsandvisualizedanalysis
AT yujiefeng knowledgedomainsandemergingtrendsinimmunerelatedadverseeventsfromimmunecheckpointinhibitorsabibliometricsandvisualizedanalysis
AT guangweiliu knowledgedomainsandemergingtrendsinimmunerelatedadverseeventsfromimmunecheckpointinhibitorsabibliometricsandvisualizedanalysis