IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma
Lung adenocarcinoma is one of the leading causes of cancer-related death worldwide. Low expression of Interleukin-33 (IL-33) was reported to be associated with the progression of pulmonary adenocarcinoma. However, the IL-33-mediated immunoregulation in pulmonary adenocarcinoma remains unclear. In th...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1596926 |
| _version_ | 1818140121318293504 |
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| author | Jiguang Zhang Yangming Chen Kai Chen Yunchao Huang Xunyu Xu Qianshun Chen Chen Huang Jiewei Luo Xing Lin |
| author_facet | Jiguang Zhang Yangming Chen Kai Chen Yunchao Huang Xunyu Xu Qianshun Chen Chen Huang Jiewei Luo Xing Lin |
| author_sort | Jiguang Zhang |
| collection | DOAJ |
| description | Lung adenocarcinoma is one of the leading causes of cancer-related death worldwide. Low expression of Interleukin-33 (IL-33) was reported to be associated with the progression of pulmonary adenocarcinoma. However, the IL-33-mediated immunoregulation in pulmonary adenocarcinoma remains unclear. In this study, we found that IL-33 treatment evidently repressed tumour growth, induced CD4+ T cells infiltration and IL-17 expression in pulmonary adenocarcinoma. Notably, IL-33 treatment increased the number of Dendritic Cells (DCs) in pulmonary adenocarcinoma. More importantly, IL-33 induced maturation and regulated the function of DCs by increasing expression of DCs mature markers (CD40 and CD80, CD86) DCs-function-related gene including antigen presentation genes (HLA-DMA, HLA-DMB and CD74) and cytokines (IL-1β, IL-6 and TNF). Mechanistic studies demonstrated that IL-33 treatment induced DCs maturation by upregulating CYLD expression in DCs. In addition, CYLD played an important role in DCs-induced T cell proliferation and IL-17 secretion. In conclusion, our study demonstrated that IL-33 mediated immunoregulation in pulmonary adenocarcinoma by improving DC-induced T cell proliferation by upregulating CYLD expression. |
| first_indexed | 2024-12-11T10:38:57Z |
| format | Article |
| id | doaj.art-41268b5f24f44f219aa93812116ce515 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-12-11T10:38:57Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-41268b5f24f44f219aa93812116ce5152022-12-22T01:10:38ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2019-12-014711335134110.1080/21691401.2019.1596926IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinomaJiguang Zhang0Yangming Chen1Kai Chen2Yunchao Huang3Xunyu Xu4Qianshun Chen5Chen Huang6Jiewei Luo7Xing Lin8Department of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of thoracic surgery, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of traditional Chinese medicine, Fujian Province Hospital, School of clinical medicine, Fujian Medical University, Fuzhou, Fujian, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian, ChinaLung adenocarcinoma is one of the leading causes of cancer-related death worldwide. Low expression of Interleukin-33 (IL-33) was reported to be associated with the progression of pulmonary adenocarcinoma. However, the IL-33-mediated immunoregulation in pulmonary adenocarcinoma remains unclear. In this study, we found that IL-33 treatment evidently repressed tumour growth, induced CD4+ T cells infiltration and IL-17 expression in pulmonary adenocarcinoma. Notably, IL-33 treatment increased the number of Dendritic Cells (DCs) in pulmonary adenocarcinoma. More importantly, IL-33 induced maturation and regulated the function of DCs by increasing expression of DCs mature markers (CD40 and CD80, CD86) DCs-function-related gene including antigen presentation genes (HLA-DMA, HLA-DMB and CD74) and cytokines (IL-1β, IL-6 and TNF). Mechanistic studies demonstrated that IL-33 treatment induced DCs maturation by upregulating CYLD expression in DCs. In addition, CYLD played an important role in DCs-induced T cell proliferation and IL-17 secretion. In conclusion, our study demonstrated that IL-33 mediated immunoregulation in pulmonary adenocarcinoma by improving DC-induced T cell proliferation by upregulating CYLD expression.https://www.tandfonline.com/doi/10.1080/21691401.2019.1596926Interleukin 33pulmonary adenocarcinomaDCsCYLDCD4+ T cellsIL-17 |
| spellingShingle | Jiguang Zhang Yangming Chen Kai Chen Yunchao Huang Xunyu Xu Qianshun Chen Chen Huang Jiewei Luo Xing Lin IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma Artificial Cells, Nanomedicine, and Biotechnology Interleukin 33 pulmonary adenocarcinoma DCs CYLD CD4+ T cells IL-17 |
| title | IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma |
| title_full | IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma |
| title_fullStr | IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma |
| title_full_unstemmed | IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma |
| title_short | IL-33 drives the antitumour effects of dendritic cells via upregulating CYLD expression in pulmonary adenocarcinoma |
| title_sort | il 33 drives the antitumour effects of dendritic cells via upregulating cyld expression in pulmonary adenocarcinoma |
| topic | Interleukin 33 pulmonary adenocarcinoma DCs CYLD CD4+ T cells IL-17 |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1596926 |
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