Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i>
Seven new lobane diterpenoids, namely, lobocatalens A–G (<b>1</b>–<b>7</b>), were isolated from the Xisha soft coral <i>Lobophytum catalai</i>. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/4/223 |
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| author | Jiarui Zhang Huixue Ma Shuangshuang Jin Xuehuan Liu Lei Li Zhaonan Liu Guoqiang Li Pinglin Li |
| author_facet | Jiarui Zhang Huixue Ma Shuangshuang Jin Xuehuan Liu Lei Li Zhaonan Liu Guoqiang Li Pinglin Li |
| author_sort | Jiarui Zhang |
| collection | DOAJ |
| description | Seven new lobane diterpenoids, namely, lobocatalens A–G (<b>1</b>–<b>7</b>), were isolated from the Xisha soft coral <i>Lobophytum catalai</i>. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (<b>1</b>) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound <b>7</b> showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line. |
| first_indexed | 2024-03-11T04:48:28Z |
| format | Article |
| id | doaj.art-41271571ad414c58ad444f0d614267c6 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T04:48:28Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-41271571ad414c58ad444f0d614267c62023-11-17T20:10:13ZengMDPI AGMarine Drugs1660-33972023-03-0121422310.3390/md21040223Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i>Jiarui Zhang0Huixue Ma1Shuangshuang Jin2Xuehuan Liu3Lei Li4Zhaonan Liu5Guoqiang Li6Pinglin Li7Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaSeven new lobane diterpenoids, namely, lobocatalens A–G (<b>1</b>–<b>7</b>), were isolated from the Xisha soft coral <i>Lobophytum catalai</i>. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (<b>1</b>) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound <b>7</b> showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.https://www.mdpi.com/1660-3397/21/4/223<i>Lobophytum catalai</i>lobocatalens A–Globane diterpenoidsanti-inflammatory activitycytotoxic activity |
| spellingShingle | Jiarui Zhang Huixue Ma Shuangshuang Jin Xuehuan Liu Lei Li Zhaonan Liu Guoqiang Li Pinglin Li Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> Marine Drugs <i>Lobophytum catalai</i> lobocatalens A–G lobane diterpenoids anti-inflammatory activity cytotoxic activity |
| title | Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> |
| title_full | Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> |
| title_fullStr | Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> |
| title_full_unstemmed | Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> |
| title_short | Seven New Lobane Diterpenoids from the Soft Coral <i>Lobophytum catalai</i> |
| title_sort | seven new lobane diterpenoids from the soft coral i lobophytum catalai i |
| topic | <i>Lobophytum catalai</i> lobocatalens A–G lobane diterpenoids anti-inflammatory activity cytotoxic activity |
| url | https://www.mdpi.com/1660-3397/21/4/223 |
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