The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials
Background: We performed a meta-analysis to examine the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). Methods: Using four databases, a systematic search was performed up to May 2022 using relevant keywords. To analyze the impact of combined trials, we applied t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622004662 |
| _version_ | 1828067453667639296 |
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| author | Mehdi Sadeghian Sepideh Rahmani Arash Jafarieh Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Mehdi Sadeghian Sepideh Rahmani Arash Jafarieh Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Mehdi Sadeghian |
| collection | DOAJ |
| description | Background: We performed a meta-analysis to examine the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). Methods: Using four databases, a systematic search was performed up to May 2022 using relevant keywords. To analyze the impact of combined trials, we applied the weighted mean difference (WMD) in a random-effects model. Results: In total, 14 studies were included in the meta-analysis. We found an overall significant effect of oral curcumin supplementation on improved creatinine (WMD: −0.08, 95 % CI: −0.14, −0.03 mg/dL; P = 0.004). Serum levels of BUN increased following curcumin supplementation (WMD: 0.41, 95 % CI: −0.23, 1.05 mg/dL; P < 0.001). In the subgroup analysis, curcumin showed significantly favorable effects on serum BUN in trials with longer duration of curcumin intervention. Conclusion: Oral curcumin with high bioavailability has a positive impact on serum levels of creatinine and BUN when supplemented for > 8 weeks in patients with inflammatory diseases. |
| first_indexed | 2024-04-10T23:45:42Z |
| format | Article |
| id | doaj.art-4127a463381c44569da30ec84e40efdf |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T23:45:42Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-4127a463381c44569da30ec84e40efdf2023-01-11T04:28:22ZengElsevierJournal of Functional Foods1756-46462023-01-01100105396The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trialsMehdi Sadeghian0Sepideh Rahmani1Arash Jafarieh2Tannaz Jamialahmadi3Amirhossein Sahebkar4Associate Faculty, YAS Hospital, Tehran University of Medical Sciences, Tehran, IranFood Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Anesthesia, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, IranSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Background: We performed a meta-analysis to examine the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). Methods: Using four databases, a systematic search was performed up to May 2022 using relevant keywords. To analyze the impact of combined trials, we applied the weighted mean difference (WMD) in a random-effects model. Results: In total, 14 studies were included in the meta-analysis. We found an overall significant effect of oral curcumin supplementation on improved creatinine (WMD: −0.08, 95 % CI: −0.14, −0.03 mg/dL; P = 0.004). Serum levels of BUN increased following curcumin supplementation (WMD: 0.41, 95 % CI: −0.23, 1.05 mg/dL; P < 0.001). In the subgroup analysis, curcumin showed significantly favorable effects on serum BUN in trials with longer duration of curcumin intervention. Conclusion: Oral curcumin with high bioavailability has a positive impact on serum levels of creatinine and BUN when supplemented for > 8 weeks in patients with inflammatory diseases.http://www.sciencedirect.com/science/article/pii/S1756464622004662Blood urea nitrogenCreatinineCurcumin meta-analysis |
| spellingShingle | Mehdi Sadeghian Sepideh Rahmani Arash Jafarieh Tannaz Jamialahmadi Amirhossein Sahebkar The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials Journal of Functional Foods Blood urea nitrogen Creatinine Curcumin meta-analysis |
| title | The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials |
| title_full | The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials |
| title_fullStr | The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials |
| title_full_unstemmed | The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials |
| title_short | The effect of curcumin supplementation on renal function: A systematic and meta-analysis of randomized controlled trials |
| title_sort | effect of curcumin supplementation on renal function a systematic and meta analysis of randomized controlled trials |
| topic | Blood urea nitrogen Creatinine Curcumin meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622004662 |
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