Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug
This article reports a microgravimetric method for the quantitative determination of metformin in bulk and in pharmaceutical preparations. The analysis is simple and relatively rapid. A complete analysis can be performed in only an hour and thirty minutes due to the drying procedure of the precipita...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2018-04-01
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| Series: | Eclética Química |
| Online Access: | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/56 |
| _version_ | 1818258471696465920 |
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| author | Matthieu Tubino Luís Francisco Bianchessi Marta Maria Duarte Carvalho Vila |
| author_facet | Matthieu Tubino Luís Francisco Bianchessi Marta Maria Duarte Carvalho Vila |
| author_sort | Matthieu Tubino |
| collection | DOAJ |
| description | This article reports a microgravimetric method for the quantitative determination of metformin in bulk and in pharmaceutical preparations. The analysis is simple and relatively rapid. A complete analysis can be performed in only an hour and thirty minutes due to the drying procedure of the precipitate. However a sample can be treated every each five minutes. The method is based on the reaction of nickel (II) with metformin that in basic medium forms an orange precipitate. The reaction is performed in a plastic syringe. The filtration was done in a glass tube containing a sintered glass disk or in Millipore® syringe filters, with posterior weighing after drying. The analytical results were statistically compared with that obtained with a HPLC and with the titrimetric method suggested by the United States and by the Japanese pharmacopoeias. |
| first_indexed | 2024-12-12T18:00:05Z |
| format | Article |
| id | doaj.art-412911de2f3a48618f8f5d7f962c629e |
| institution | Directory Open Access Journal |
| issn | 1678-4618 |
| language | English |
| last_indexed | 2024-12-12T18:00:05Z |
| publishDate | 2018-04-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Eclética Química |
| spelling | doaj.art-412911de2f3a48618f8f5d7f962c629e2022-12-22T00:16:37ZengUniversidade Estadual PaulistaEclética Química1678-46182018-04-01401627010.26850/1678-4618eqj.v40.1.2015.p62-7056Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drugMatthieu Tubino0Luís Francisco Bianchessi1Marta Maria Duarte Carvalho Vila2Institute of Chemistry, University of Campinas, Campinas, SP, Brazil 13083-970 P.O. Box 6154Institute of Chemistry, University of Campinas, Campinas, SP, 13083-970 P.O. Box 6154University of Sorocaba, Sorocaba, SP, 13087-000This article reports a microgravimetric method for the quantitative determination of metformin in bulk and in pharmaceutical preparations. The analysis is simple and relatively rapid. A complete analysis can be performed in only an hour and thirty minutes due to the drying procedure of the precipitate. However a sample can be treated every each five minutes. The method is based on the reaction of nickel (II) with metformin that in basic medium forms an orange precipitate. The reaction is performed in a plastic syringe. The filtration was done in a glass tube containing a sintered glass disk or in Millipore® syringe filters, with posterior weighing after drying. The analytical results were statistically compared with that obtained with a HPLC and with the titrimetric method suggested by the United States and by the Japanese pharmacopoeias.https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/56 |
| spellingShingle | Matthieu Tubino Luís Francisco Bianchessi Marta Maria Duarte Carvalho Vila Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug Eclética Química |
| title | Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| title_full | Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| title_fullStr | Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| title_full_unstemmed | Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| title_short | Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| title_sort | microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug |
| url | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/56 |
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