Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis
Abstract Background Synchronous cancer in patients with abdominal aortic aneurysm (AAA) increases morbidity and mortality after AAA repair. However, little is known about the impact of the history of cancer on mortality after AAA repair. Methods Patients with intact AAA who were treated with endovas...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s12893-020-00754-3 |
| _version_ | 1811216929510129664 |
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| author | Sanghyun Ahn Jin-Young Min Hyunyoung G. Kim Hyejin Mo Seung-Kee Min Sangil Min Jongwon Ha Kyoung-Bok Min |
| author_facet | Sanghyun Ahn Jin-Young Min Hyunyoung G. Kim Hyejin Mo Seung-Kee Min Sangil Min Jongwon Ha Kyoung-Bok Min |
| author_sort | Sanghyun Ahn |
| collection | DOAJ |
| description | Abstract Background Synchronous cancer in patients with abdominal aortic aneurysm (AAA) increases morbidity and mortality after AAA repair. However, little is known about the impact of the history of cancer on mortality after AAA repair. Methods Patients with intact AAA who were treated with endovascular aneurysm repair or open surgical repair were selected from the Health Insurance and Review Assessment data in South Korea between 2007 and 2016. Primary endpoints included the 30- and 90-day mortality and long-term mortality after AAA repair. The Cox proportional hazards models were constructed to evaluate independent predictors of mortality. Results A total of 1999 patients (17.0%, 1999/11785) were diagnosed with cancer prior to the AAA repair. History of cancer generally had no effect in short-term mortality at 30 and 90 days. However, short-term mortality rate of patients with a history of lung cancer was more than twice that of patients without it (3.07% vs. 1.06%, P = 0.0038, 6.14% vs. 2.69%, P = 0.0016). Furthermore, the mortality rate at the end of the study period was significantly higher in AAA patients with a history of cancer than in those without a history of cancer (21.21% vs. 17.08%, P < .0001, HR, 1.31, 95% CI, 1.17–1.46). Conclusions The history of cancer in AAA patients increases long-term mortality but does not affect short-term mortality after AAA repair. However, AAA repair could increase both short- and long-term mortality in patients with lung cancer history, and those cases should be more carefully selected. |
| first_indexed | 2024-04-12T06:45:47Z |
| format | Article |
| id | doaj.art-412947b7f27944409b31c021d745428d |
| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-04-12T06:45:47Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj.art-412947b7f27944409b31c021d745428d2022-12-22T03:43:33ZengBMCBMC Surgery1471-24822020-05-012011910.1186/s12893-020-00754-3Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysisSanghyun Ahn0Jin-Young Min1Hyunyoung G. Kim2Hyejin Mo3Seung-Kee Min4Sangil Min5Jongwon Ha6Kyoung-Bok Min7Division of Vascular Surgery, Department of Surgery, Seoul National University College of MedicineInstitute of Health and Environment, Seoul National UniversityDepartment of Family and Community Medicine, University of Texas Health Sciences Center at San AntonioDivision of Vascular Surgery, Department of Surgery, Seoul National University College of MedicineDivision of Vascular Surgery, Department of Surgery, Seoul National University College of MedicineDivision of Vascular Surgery, Department of Surgery, Seoul National University College of MedicineDivision of Vascular Surgery, Department of Surgery, Seoul National University College of MedicineDepartment of Preventive Medicine, Seoul National University College of MedicineAbstract Background Synchronous cancer in patients with abdominal aortic aneurysm (AAA) increases morbidity and mortality after AAA repair. However, little is known about the impact of the history of cancer on mortality after AAA repair. Methods Patients with intact AAA who were treated with endovascular aneurysm repair or open surgical repair were selected from the Health Insurance and Review Assessment data in South Korea between 2007 and 2016. Primary endpoints included the 30- and 90-day mortality and long-term mortality after AAA repair. The Cox proportional hazards models were constructed to evaluate independent predictors of mortality. Results A total of 1999 patients (17.0%, 1999/11785) were diagnosed with cancer prior to the AAA repair. History of cancer generally had no effect in short-term mortality at 30 and 90 days. However, short-term mortality rate of patients with a history of lung cancer was more than twice that of patients without it (3.07% vs. 1.06%, P = 0.0038, 6.14% vs. 2.69%, P = 0.0016). Furthermore, the mortality rate at the end of the study period was significantly higher in AAA patients with a history of cancer than in those without a history of cancer (21.21% vs. 17.08%, P < .0001, HR, 1.31, 95% CI, 1.17–1.46). Conclusions The history of cancer in AAA patients increases long-term mortality but does not affect short-term mortality after AAA repair. However, AAA repair could increase both short- and long-term mortality in patients with lung cancer history, and those cases should be more carefully selected.http://link.springer.com/article/10.1186/s12893-020-00754-3Abdominal aortic aneurysmCancerMortality |
| spellingShingle | Sanghyun Ahn Jin-Young Min Hyunyoung G. Kim Hyejin Mo Seung-Kee Min Sangil Min Jongwon Ha Kyoung-Bok Min Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis BMC Surgery Abdominal aortic aneurysm Cancer Mortality |
| title | Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis |
| title_full | Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis |
| title_fullStr | Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis |
| title_full_unstemmed | Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis |
| title_short | Outcomes after aortic aneurysm repair in patients with history of cancer: a nationwide dataset analysis |
| title_sort | outcomes after aortic aneurysm repair in patients with history of cancer a nationwide dataset analysis |
| topic | Abdominal aortic aneurysm Cancer Mortality |
| url | http://link.springer.com/article/10.1186/s12893-020-00754-3 |
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