Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase
Essential oils (EOs) are known to possess lethal effects on various pests and insects and are ecologically safe. The larvicidal and adulticidal activities of Helianthus annuus (L.) seed EO (HASEO) against Aedes aegypti mosquitoes and in silico inhibitory action of its GCMS constituents against Ae. a...
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Elsevier
2024-01-01
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| Series: | Informatics in Medicine Unlocked |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352914824000029 |
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| author | Babasoji Percy Omoniwa Titilayo Omolara Johnson Marvellous Amarachi Acho Charles Obiora Nwonuma Omolola Soji-Omoniwa Adekemi Grace Oluwafemi Blessing Eshionimi Tomo Kayode Odejobi Omokolade Alejolowo Emmanuel Olorunleke Oludipe |
| author_facet | Babasoji Percy Omoniwa Titilayo Omolara Johnson Marvellous Amarachi Acho Charles Obiora Nwonuma Omolola Soji-Omoniwa Adekemi Grace Oluwafemi Blessing Eshionimi Tomo Kayode Odejobi Omokolade Alejolowo Emmanuel Olorunleke Oludipe |
| author_sort | Babasoji Percy Omoniwa |
| collection | DOAJ |
| description | Essential oils (EOs) are known to possess lethal effects on various pests and insects and are ecologically safe. The larvicidal and adulticidal activities of Helianthus annuus (L.) seed EO (HASEO) against Aedes aegypti mosquitoes and in silico inhibitory action of its GCMS constituents against Ae. aegypti acetylcholinesterase (AChE) were investigated. Larvae and adult Ae. aegypti (320 of each) were grouped into 4 (A - D) and exposed to DMSO, 1500, 3000 and 4500 ppm HASEO in DMSO respectively. Mortality was recorded after 0, 15, 30 and 45 min. HASEO exhibited stronger larvicidal activity than adulticidal activity against Ae. aegypti. The larvicidal and adulticidal activities of HASEO increased with increasing exposure time, with the highest mortality recorded after 45 min of exposure (larvicidal activity LC50- 2121.32 ppm; adulticidal activity LC50- 2565.20 ppm). Increase in the concentration of HASEO resulted in an increase in the larvicidal and adulticidal activities of HASEO. After 45 min of exposure, 100 % larvae mortality was recorded at 3000 and 4500 ppm HASEO while 100 % adult mortality was recorded at 4500 ppm HASEO. GCMS analysis revealed the presence of 21 compounds in HASEO with 1-chlorononadecane (23.67 %) being the most abundant compound. Two compounds of HASEO; isopinocamphone and oxazol-5(4H)-one, 4-(4-trifluoromethylbenzylidene)-2-(2-methylphenyl)- demonstrated potential inhibitory activity against Ae. aegypti AChE with comparable binding affinity to standard ligand (1S)-2,2-difluoro-1-[1-(pentan-3-yl)-1H-pyrazol-4-yl]ethan-1-ol. The present findings reveal that HASEO may be useful as an effective biopesticide for the control of Ae. aegypti adult and larvae and may serve as an alternative to synthetic insecticides. |
| first_indexed | 2024-03-07T14:00:55Z |
| format | Article |
| id | doaj.art-412ccb266a4d4e07bb54693481e2e0ab |
| institution | Directory Open Access Journal |
| issn | 2352-9148 |
| language | English |
| last_indexed | 2024-03-07T14:00:55Z |
| publishDate | 2024-01-01 |
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| series | Informatics in Medicine Unlocked |
| spelling | doaj.art-412ccb266a4d4e07bb54693481e2e0ab2024-03-07T05:28:08ZengElsevierInformatics in Medicine Unlocked2352-91482024-01-0145101446Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesteraseBabasoji Percy Omoniwa0Titilayo Omolara Johnson1Marvellous Amarachi Acho2Charles Obiora Nwonuma3Omolola Soji-Omoniwa4Adekemi Grace Oluwafemi5Blessing Eshionimi Tomo6Kayode Odejobi7Omokolade Alejolowo8Emmanuel Olorunleke Oludipe9Ethnopharmacology, Reproductive Biochemistry and Biochemical Toxicology Laboratory, Department of Science Laboratory Technology, Faculty of Natural Sciences, University of Jos, Plateau State, Nigeria; Department of Biochemistry, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, Nigeria; Corresponding author. Ethnopharmacology, Reproductive Biochemistry and Biochemical Toxicology Laboratory, Department of Science Laboratory Technology, Faculty of Natural Sciences, University of Jos, Plateau State, Nigeria.Department of Biochemistry, Faculty of Basic Medical Sciences, University of Jos, Plateau State, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, NigeriaDepartment of Biochemistry, Faculty of Life Sciences, University of Ilorin, Kwara State, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, NigeriaEthnopharmacology, Reproductive Biochemistry and Biochemical Toxicology Laboratory, Department of Science Laboratory Technology, Faculty of Natural Sciences, University of Jos, Plateau State, NigeriaEthnopharmacology, Reproductive Biochemistry and Biochemical Toxicology Laboratory, Department of Science Laboratory Technology, Faculty of Natural Sciences, University of Jos, Plateau State, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, NigeriaDepartment of Food Science and Microbiology, College of Pure and Applied Sciences, Landmark University, Omu-Aran, Kwara State, NigeriaEssential oils (EOs) are known to possess lethal effects on various pests and insects and are ecologically safe. The larvicidal and adulticidal activities of Helianthus annuus (L.) seed EO (HASEO) against Aedes aegypti mosquitoes and in silico inhibitory action of its GCMS constituents against Ae. aegypti acetylcholinesterase (AChE) were investigated. Larvae and adult Ae. aegypti (320 of each) were grouped into 4 (A - D) and exposed to DMSO, 1500, 3000 and 4500 ppm HASEO in DMSO respectively. Mortality was recorded after 0, 15, 30 and 45 min. HASEO exhibited stronger larvicidal activity than adulticidal activity against Ae. aegypti. The larvicidal and adulticidal activities of HASEO increased with increasing exposure time, with the highest mortality recorded after 45 min of exposure (larvicidal activity LC50- 2121.32 ppm; adulticidal activity LC50- 2565.20 ppm). Increase in the concentration of HASEO resulted in an increase in the larvicidal and adulticidal activities of HASEO. After 45 min of exposure, 100 % larvae mortality was recorded at 3000 and 4500 ppm HASEO while 100 % adult mortality was recorded at 4500 ppm HASEO. GCMS analysis revealed the presence of 21 compounds in HASEO with 1-chlorononadecane (23.67 %) being the most abundant compound. Two compounds of HASEO; isopinocamphone and oxazol-5(4H)-one, 4-(4-trifluoromethylbenzylidene)-2-(2-methylphenyl)- demonstrated potential inhibitory activity against Ae. aegypti AChE with comparable binding affinity to standard ligand (1S)-2,2-difluoro-1-[1-(pentan-3-yl)-1H-pyrazol-4-yl]ethan-1-ol. The present findings reveal that HASEO may be useful as an effective biopesticide for the control of Ae. aegypti adult and larvae and may serve as an alternative to synthetic insecticides.http://www.sciencedirect.com/science/article/pii/S2352914824000029Essential oilsInsecticidesBiological control agentsHelianthusGas chromatography mass spectrometry |
| spellingShingle | Babasoji Percy Omoniwa Titilayo Omolara Johnson Marvellous Amarachi Acho Charles Obiora Nwonuma Omolola Soji-Omoniwa Adekemi Grace Oluwafemi Blessing Eshionimi Tomo Kayode Odejobi Omokolade Alejolowo Emmanuel Olorunleke Oludipe Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase Informatics in Medicine Unlocked Essential oils Insecticides Biological control agents Helianthus Gas chromatography mass spectrometry |
| title | Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase |
| title_full | Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase |
| title_fullStr | Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase |
| title_full_unstemmed | Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase |
| title_short | Larvicidal and adulticidal activities of essential oil of Helianthus annuus (L.) seed and molecular docking of its GCMS constituents against Aedes aegypti acetylcholinesterase |
| title_sort | larvicidal and adulticidal activities of essential oil of helianthus annuus l seed and molecular docking of its gcms constituents against aedes aegypti acetylcholinesterase |
| topic | Essential oils Insecticides Biological control agents Helianthus Gas chromatography mass spectrometry |
| url | http://www.sciencedirect.com/science/article/pii/S2352914824000029 |
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