Dimensional clinical phenotyping using post‐mortem brain donor medical records: post‐mortem RDoC profiling is associated with Alzheimer's disease neuropathology

Abstract Introduction Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to post‐mortem work, as assessments of phenotypic concepts need to rely on existing records. Meth...

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Bibliographic Details
Main Authors: Jonathan Vogelgsang, Shu Dan, Anna P. Lally, Michael Chatigny, Sangeetha Vempati, Joshua Abston, Peter T. Durning, Derek H. Oakley, Thomas H. McCoy, Torsten Klengel, Sabina Berretta
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Online Access:https://doi.org/10.1002/dad2.12464