Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches

Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches

Abstract Aβ-amyloid deposition is a key feature of Alzheimer’s disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal phase is based on a neuroanatomical hierarchy of Aβ-deposi...

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Bibliographic Details
Main Authors: S. B. Wharton, D. Wang, C. Parikh, F. E. Matthews, C. Brayne, P. G. Ince, on behalf of the Cognitive Function and Ageing Neuropathology Study Group
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-019-0858-4

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