Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/17/5/5339 |
| _version_ | 1819096861391192064 |
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| author | Ke-Hua Zhang Jing-Jing Xia |
| author_facet | Ke-Hua Zhang Jing-Jing Xia |
| author_sort | Ke-Hua Zhang |
| collection | DOAJ |
| description | Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields. |
| first_indexed | 2024-12-22T00:05:55Z |
| format | Article |
| id | doaj.art-412f5389ac8a40d998aeb3eafb3f27fd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T00:05:55Z |
| publishDate | 2012-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-412f5389ac8a40d998aeb3eafb3f27fd2022-12-21T18:45:34ZengMDPI AGMolecules1420-30492012-05-011755339534510.3390/molecules17055339Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing WaterKe-Hua ZhangJing-Jing XiaAcridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing good to excellent yields.http://www.mdpi.com/1420-3049/17/5/5339acridinedionepolyhydroquinolineone-pot reactionwater |
| spellingShingle | Ke-Hua Zhang Jing-Jing Xia Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water Molecules acridinedione polyhydroquinoline one-pot reaction water |
| title | Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water |
| title_full | Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water |
| title_fullStr | Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water |
| title_full_unstemmed | Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water |
| title_short | Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water |
| title_sort | synthesis of lt em gt n lt em gt substituted acridinediones and polyhydroquinoline derivatives in refluxing water |
| topic | acridinedione polyhydroquinoline one-pot reaction water |
| url | http://www.mdpi.com/1420-3049/17/5/5339 |
| work_keys_str_mv | AT kehuazhang synthesisofltemgtnltemgtsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater AT jingjingxia synthesisofltemgtnltemgtsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater |