Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy
Background: Intrahepatic cholestasis of pregnancy (IHCP) is a hepatic disorder associated specifically with pregnancy. It is found to affect both mother and fetus. It requires detailed clinical and biochemical evaluation for optimal feto-maternal outcome. Objectives: To study the demographic profil...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Barpeta Obstetrics and Gynaecological Society
2023-02-01
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| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/09302.pdf |
| _version_ | 1797902070566617088 |
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| author | Vineeta Gupta Alvina Rehman Shweta Nimonkar Priyanka Chaudhari Namrata Saxena |
| author_facet | Vineeta Gupta Alvina Rehman Shweta Nimonkar Priyanka Chaudhari Namrata Saxena |
| author_sort | Vineeta Gupta |
| collection | DOAJ |
| description | Background: Intrahepatic cholestasis of pregnancy (IHCP) is a hepatic disorder associated specifically with pregnancy. It is found to affect both mother and fetus. It requires detailed clinical and biochemical evaluation for optimal feto-maternal outcome. Objectives: To study the demographic profile, clinical features and obstetric outcome in patients with intrahepatic cholestasis of pregnancy and to assess correlation between serum bile acid levels and perinatal outcome. Material and methods: This was a prospective study conducted on 150 pregnant women with IHCP who delivered at our tertiary care centre, Shri Mahant Indiresh Hospital, Dehradun from September 2018 – June 2020. The relationship between serum bile acid levels and fetal complications was analysed with binary logistic regression method. Results: The incidence of IHCP at our centre was found to be 2.82%. We found that 59.94% patients had bile acid levels between 10-40 µmol/L, 36.6% patients bile acid levels between 41-100 µmol/L and 3.33% patients had bile acid levels >100 µmol/L. The correlation between serum bile acid levels with onset of labour and mode of delivery was not statistically significant (p-value 0.16 and 0.556 respectively). The correlation between serum bile acid levels with meconium stained liquor, NICU admission and prematurity was found to be statistically significant with p-value of <0.001, 0.007 and 0.018 respectively. Conclusion: Symptomatic women should be subjected to estimation of serum bile acid levels so that appropriate treatment and timely intervention can be done to optimize obstetric outcome. |
| first_indexed | 2024-04-10T09:11:59Z |
| format | Article |
| id | doaj.art-412fc19933c042dc9c4d419c5aaad819 |
| institution | Directory Open Access Journal |
| issn | 2454-2334 2454-2342 |
| language | English |
| last_indexed | 2024-04-10T09:11:59Z |
| publishDate | 2023-02-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj.art-412fc19933c042dc9c4d419c5aaad8192023-02-21T04:18:02ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422023-02-019230230710.21276/obgyn.2023.9.2.22Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancyVineeta Gupta 0Alvina Rehman 1Shweta Nimonkar 2Priyanka Chaudhari 3Namrata Saxena 4Prof & Head, Department of Obstetrics and Gynaecology, SGRRIHM&S & Shri Mahant Indiresh Hospital, Patel Nagar, Dehradun, Uttarakhand, IndiaJunior Resident, Department of Obstetrics and Gynaecology, SGRRIHM&S & Shri Mahant Indiresh Hospital, Patel Nagar, Dehradun, Uttarakhand, IndiaAssociate Professor, Department of Obstetrics and Gynaecology, SGRRIHM&S & Shri Mahant Indiresh Hospital, Patel Nagar, Dehradun, Uttarakhand, India4 Professor, Department of Obstetrics and Gynaecology, SGRRIHM&S & Shri Mahant Indiresh Hospital, Patel Nagar, Dehradun, Uttarakhand, IndiaAssociate Professor, Department of Obstetrics and Gynaecology, SGRRIHM&S & Shri Mahant Indiresh Hospital, Patel Nagar, Dehradun, Uttarakhand, IndiaBackground: Intrahepatic cholestasis of pregnancy (IHCP) is a hepatic disorder associated specifically with pregnancy. It is found to affect both mother and fetus. It requires detailed clinical and biochemical evaluation for optimal feto-maternal outcome. Objectives: To study the demographic profile, clinical features and obstetric outcome in patients with intrahepatic cholestasis of pregnancy and to assess correlation between serum bile acid levels and perinatal outcome. Material and methods: This was a prospective study conducted on 150 pregnant women with IHCP who delivered at our tertiary care centre, Shri Mahant Indiresh Hospital, Dehradun from September 2018 – June 2020. The relationship between serum bile acid levels and fetal complications was analysed with binary logistic regression method. Results: The incidence of IHCP at our centre was found to be 2.82%. We found that 59.94% patients had bile acid levels between 10-40 µmol/L, 36.6% patients bile acid levels between 41-100 µmol/L and 3.33% patients had bile acid levels >100 µmol/L. The correlation between serum bile acid levels with onset of labour and mode of delivery was not statistically significant (p-value 0.16 and 0.556 respectively). The correlation between serum bile acid levels with meconium stained liquor, NICU admission and prematurity was found to be statistically significant with p-value of <0.001, 0.007 and 0.018 respectively. Conclusion: Symptomatic women should be subjected to estimation of serum bile acid levels so that appropriate treatment and timely intervention can be done to optimize obstetric outcome.https://journal.barpetaogs.co.in/pdf/09302.pdfintrahepatic cholestasis of pregnancypruritisserum bile acidsmeconium stained liquorursodeoxycholic acid |
| spellingShingle | Vineeta Gupta Alvina Rehman Shweta Nimonkar Priyanka Chaudhari Namrata Saxena Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy New Indian Journal of OBGYN intrahepatic cholestasis of pregnancy pruritis serum bile acids meconium stained liquor ursodeoxycholic acid |
| title | Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| title_full | Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| title_fullStr | Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| title_full_unstemmed | Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| title_short | Obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| title_sort | obstetric outcome of elevated total serum bile acid levels in women with intrahepatic cholestasis of pregnancy |
| topic | intrahepatic cholestasis of pregnancy pruritis serum bile acids meconium stained liquor ursodeoxycholic acid |
| url | https://journal.barpetaogs.co.in/pdf/09302.pdf |
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