Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber
Background: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to investigate whether there was an improvement in gly...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-09-01
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| Series: | Nutrition and Metabolic Insights |
| Online Access: | https://doi.org/10.1177/11786388221125181 |
| _version_ | 1811208671813697536 |
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| author | Mykola D Khalangot Vitaly G Gurianov Tamara F Zakharchenko Yurii M Pysarenko Victor I Kravchenko |
| author_facet | Mykola D Khalangot Vitaly G Gurianov Tamara F Zakharchenko Yurii M Pysarenko Victor I Kravchenko |
| author_sort | Mykola D Khalangot |
| collection | DOAJ |
| description | Background: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to investigate whether there was an improvement in glycemia and body composition in individuals at risk for T2D after 3 months of IF consumption. Methods: This “Type 2 Diabetes Mellitus Prevention Ukraine (T2DPUA)” study describes participants with impaired fasting glucose (IFG) as determined by ADA criteria. The study involved 30 people, including 21 women (70%). Daily, 15 g of IF derived from wheat was used. T2DPUA did not have a placebo group and the intervention lasted 3 months. Evaluation of fasting plasma glucose (FPG) and 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), total cholesterol, HDL-cholesterol, triacylglycerols, uric acid, and γ-glutamyl transferase was performed. The baseline and 3-monthly anthropometric examinations included measurements of weight, waist and hip circumference. Fat mass was assessed by bioelectrical impedance analysis. Paired samples t -test or Wilcoxon test were used. Result: A decrease of FPG ( P = .042), HbA1c ( P < .001), 2hPG ( P = .005), weight ( P < .001), body mass index ( P < .001), the proportion of body fat ( P = .006), and the absolute amount of fat ( P < .001), increases in systolic ( P < .001) and diastolic ( P = .008) blood pressure was shown. The number of people with hypertension did not change. The absolute amount of body fat decreased by almost 5% and tolerance to the standard glucose load improved by 15%. The dynamics of other metabolic parameters were not revealed. Conclusion and Recommendation: Data about improvement of glycemia and body composition over a short period of using IF by individuals with IFG are new and deserve larger studies. |
| first_indexed | 2024-04-12T04:26:36Z |
| format | Article |
| id | doaj.art-413109b8ce2b469ea8255e38bb4fc3cf |
| institution | Directory Open Access Journal |
| issn | 1178-6388 |
| language | English |
| last_indexed | 2024-04-12T04:26:36Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Nutrition and Metabolic Insights |
| spelling | doaj.art-413109b8ce2b469ea8255e38bb4fc3cf2022-12-22T03:48:04ZengSAGE PublishingNutrition and Metabolic Insights1178-63882022-09-011510.1177/11786388221125181Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary FiberMykola D Khalangot0Vitaly G Gurianov1Tamara F Zakharchenko2Yurii M Pysarenko3Victor I Kravchenko4Epidemiology Department, Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, UkraineMedical and Biological Physics and Informatics Department, Bogomolets National Medical University, Kyiv, UkraineEpidemiology Department, Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, UkraineMakariv District Hospital, Kyiv oblast, UkraineEpidemiology Department, Komisarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine, Kyiv, UkraineBackground: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to investigate whether there was an improvement in glycemia and body composition in individuals at risk for T2D after 3 months of IF consumption. Methods: This “Type 2 Diabetes Mellitus Prevention Ukraine (T2DPUA)” study describes participants with impaired fasting glucose (IFG) as determined by ADA criteria. The study involved 30 people, including 21 women (70%). Daily, 15 g of IF derived from wheat was used. T2DPUA did not have a placebo group and the intervention lasted 3 months. Evaluation of fasting plasma glucose (FPG) and 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), total cholesterol, HDL-cholesterol, triacylglycerols, uric acid, and γ-glutamyl transferase was performed. The baseline and 3-monthly anthropometric examinations included measurements of weight, waist and hip circumference. Fat mass was assessed by bioelectrical impedance analysis. Paired samples t -test or Wilcoxon test were used. Result: A decrease of FPG ( P = .042), HbA1c ( P < .001), 2hPG ( P = .005), weight ( P < .001), body mass index ( P < .001), the proportion of body fat ( P = .006), and the absolute amount of fat ( P < .001), increases in systolic ( P < .001) and diastolic ( P = .008) blood pressure was shown. The number of people with hypertension did not change. The absolute amount of body fat decreased by almost 5% and tolerance to the standard glucose load improved by 15%. The dynamics of other metabolic parameters were not revealed. Conclusion and Recommendation: Data about improvement of glycemia and body composition over a short period of using IF by individuals with IFG are new and deserve larger studies.https://doi.org/10.1177/11786388221125181 |
| spellingShingle | Mykola D Khalangot Vitaly G Gurianov Tamara F Zakharchenko Yurii M Pysarenko Victor I Kravchenko Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber Nutrition and Metabolic Insights |
| title | Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber |
| title_full | Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber |
| title_fullStr | Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber |
| title_full_unstemmed | Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber |
| title_short | Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber |
| title_sort | metabolic and anthropometric parameters of persons at risk of developing type 2 diabetes mellitus before and after 3 months of consuming insoluble dietary fiber |
| url | https://doi.org/10.1177/11786388221125181 |
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